Key takeaways
Febuxostat (Uloric) and probenecid (Probalan) are both antigout medications used to manage gout by lowering uric acid levels in the body. However, they work differently and have distinct uses. Febuxostat is a xanthine oxidase inhibitor that prevents the production of uric acid, while probenecid helps the kidneys remove uric acid through urine. Febuxostat is typically taken once daily and is a second-choice option after allopurinol, especially for those with kidney issues, but it carries a risk of heart-related side effects. Probenecid is taken twice daily and can also be used to boost the effectiveness of certain antibiotics, but it may cause kidney stones and is not recommended for people with severe kidney problems. Both febuxostat and probenecid are available as brand-name and generic medications. Common side effects of febuxostat include liver changes and rash, whereas probenecid may cause headaches and dizziness. Both medications can paradoxically cause more gout attacks when you first start taking them (before they get better), and they have specific drug interactions to be aware of, such as febuxostat with azathioprine (Azasan, Imuran) and probenecid with aspirin.
