Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Uloric vs. Colcrys

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Febuxostat (Uloric) and colchicine (Colcrys, Mitigare, Gloperba) are both used to manage gout, but they have several differences. Febuxostat is a once-daily medication that prevents gout flares by lowering uric acid levels in the body. But it's not recommended for people with heart conditions. Febuxostat is typically used when allopurinol is not an option. Colchicine, on the other hand, is an anti-inflammatory medication that can both treat and prevent gout flares. It is also used to treat familial Mediterranean fever (FMF). Colchicine can be taken once or twice daily for prevention or as needed for treatment, but it interacts with many medications and foods like grapefruit. Febuxostat and colchicine are both available as lower-cost generics. Both medications have serious side effects, but febuxostat is particularly noted for its risk of heart-related issues, while colchicine can cause blood problems and nerve or muscle toxicity.

  • Febuxostat (Uloric)
    Colchicine
  • Febuxostat (Uloric)
    Colchicine

  • Summary of Uloric vs. Colcrys

    Summary for Antigout
    Prescription only

    Febuxostat (Uloric) is a once daily medication that can prevent gout flares. It's a second-choice treatment option after allopurinol (Zyloprim).

    Summary for Antigout
    Prescription only

    Colchicine is used for the treatment and prevention of gout flares, but its cost and side effects limit its use. It's also a first-choice medication for treating familial Mediterranean fever (FMF). This medication comes as tablets, capsules, and an oral solution.

  • Indications of Uloric vs. Colcrys

    Indications for
    •Gout in people who can't take or haven't responded to allopurinol (Zyloprim)
    Indications for
    •Gout prevention
    •Gout treatment - tablets only
    •Familial Mediterranean fever (FMF) - tablets only

  • Pros and Cons of Uloric vs. Colcrys

    Pros and Const for Antigout
    Pros
    •Only needs to be take once a day
    •Available as a lower-cost generic medication
    •Less risk of kidney stones when compared to allopurinol (Zyloprim)
    •Taken once a day with or without food
    •Can be used in people with kidney or liver problems
    Cons
    •Can cause more gout flares when you first start
    •Not a good option for people with heart conditions
    •Should only be used if allopurinol (Zyloprim) isn't an option
    •Won't treat an acute gout attack
    Pros and Const for Antigout
    Pros
    •Can be taken once or twice a day with or without food
    •Helpful for preventing gout when people are first starting allopurinol (Zyloprim)
    •Tablets work quickly to treat gout flares if they happen
    •For tablets, dose easily adjustable based on how you respond to the medication; they're scored to make it easier to split your dose if needed
    •Tablets are a first-choice medication for treating familial Mediterranean fever (FMF)
    Cons
    •Tablets and capsules available as a generic, but can be still more expensive than other treatment options for gout like nonsteroidal anti-inflammatory drugs (NSAIDs)
    •Risk of blood problems if taken long term
    •Might need lower dose if you have kidney or liver problems
    •Interacts with a lot of medications
    •Might affect fertility in males

  • Common Side Effects of Uloric vs. Colcrys

    Common Side Effects for
    •Change in liver labs (5-7%)
    •Rash (1-2%)
    •Nausea (1%)
    •Joint pain (1%)
    Common Side Effects for
    •Diarrhea (23%)
    •Nausea (4%)

  • Warnings of Uloric vs. Colcrys

    Common Side Effects for
    •Heart problems
    •More gout attacks
    •Liver damage
    •Serious skin reaction
    Common Side Effects for
    •Life-threatening overdose
    •Blood problems
    •Medication and food interactions
    •Nerve or muscle toxicity

  • Prices with our coupons for Uloric vs. Colcrys

    Learn more about Febuxostat
    Learn more about Colchicine

Compare other Gout drugs

Uloric vs AllopurinolUloric vs BenemidUloric vs GloperbaAlbuterol vs PrednisoneDexamethasone vs PrednisoneHumira vs PrednisoneIbuprofen vs IndocinImuran vs PrednisoneIndocin vs AllopurinolIndocin vs CelebrexIndocin vs ColcrysIndocin vs FeldeneIndocin vs MeloxicamIndocin vs MobicIndocin vs PrednisoneIndocin vs TylenolKrystexxa vs GloperbaMeloxicam vs IndocinMeloxicam vs PrednisoneMethylprednisolone vs PrednisoneNaproxen vs IndocinPrednisone vs AllopurinolPrednisone vs CimziaPrednisone vs EnbrelPrednisone vs PrednisolonePrednisone vs RemicadeVoltaren vs Indocin
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.