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Compare Uloric vs. Benemid

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Febuxostat (Uloric) and probenecid (Probalan) are both antigout medications used to manage gout by lowering uric acid levels in the body. However, they work differently and have distinct uses. Febuxostat is a xanthine oxidase inhibitor that prevents the production of uric acid, while probenecid helps the kidneys remove uric acid through urine. Febuxostat is typically taken once daily and is a second-choice option after allopurinol, especially for those with kidney issues, but it carries a risk of heart-related side effects. Probenecid is taken twice daily and can also be used to boost the effectiveness of certain antibiotics, but it may cause kidney stones and is not recommended for people with severe kidney problems. Both febuxostat and probenecid are available as brand-name and generic medications. Common side effects of febuxostat include liver changes and rash, whereas probenecid may cause headaches and dizziness. Both medications can paradoxically cause more gout attacks when you first start taking them (before they get better), and they have specific drug interactions to be aware of, such as febuxostat with azathioprine (Azasan, Imuran) and probenecid with aspirin.

  • Febuxostat (Uloric)
    Probenecid
  • Febuxostat (Uloric)
    Probenecid

  • Summary of Uloric vs. Benemid

    Summary for Antigout
    Prescription only

    Febuxostat (Uloric) is a once daily medication that can prevent gout flares. It's a second-choice treatment option after allopurinol (Zyloprim).

    Summary for Antigout
    Prescription only

    Probenecid is commonly used to prevent gout attacks in the long run, but it doesn't help relieve pain and swelling during a sudden gout attack. It's also sometimes used with certain antibiotics, such as penicillin, to boost their ability to fight infections. Probenecid comes as tablets that are taken by mouth twice daily for gout. Some side effects of this medication include headache, dizziness, and sometimes kidney stones. Probenecid might also have a few interactions with other medications.

  • Indications of Uloric vs. Benemid

    Indications for
    •Gout in people who can't take or haven't responded to allopurinol (Zyloprim)
    Indications for
    •Gout (joint pain and swelling caused by high uric acid levels)
    •Boosting antibiotic activity to fight infections

  • Pros and Cons of Uloric vs. Benemid

    Pros and Const for Antigout
    Pros
    •Only needs to be take once a day
    •Available as a lower-cost generic medication
    •Less risk of kidney stones when compared to allopurinol (Zyloprim)
    •Taken once a day with or without food
    •Can be used in people with kidney or liver problems
    Cons
    •Can cause more gout flares when you first start
    •Not a good option for people with heart conditions
    •Should only be used if allopurinol (Zyloprim) isn't an option
    •Won't treat an acute gout attack
    Pros and Const for Antigout
    Pros
    •Helps treat the cause of gout
    •Can use for children 2 years and older (for treatment of infections with certain antibiotics only)
    •Available as a lower-cost generic medication
    Cons
    •Not a first-choice option for gout
    •Can't take aspirin at the same time because it might raise the risk for a gout attack
    •Might not work as well for people with severe kidney problems

  • Common Side Effects of Uloric vs. Benemid

    Common Side Effects for
    •Change in liver labs (5-7%)
    •Rash (1-2%)
    •Nausea (1%)
    •Joint pain (1%)
    Common Side Effects for
    •Headache
    •Dizziness
    •Sudden gout attack (sharp pain and swelling at the joints)
    •Nausea
    •Vomiting
    •Kidney stones

  • Warnings of Uloric vs. Benemid

    Common Side Effects for
    •Heart problems
    •More gout attacks
    •Liver damage
    •Serious skin reaction
    Common Side Effects for
    •Kidney stones
    •Risk of blood problems in certain people

  • Prices with our coupons for Uloric vs. Benemid

    Learn more about Febuxostat
    Learn more about Probenecid

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