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Thiothixene vs. Clozapine

Thiothixene is used to treat schizophrenia in people ages 12 years and older. It belongs to a drug class known as typical antipsychotics. This medication comes as a oral capsule and it's typically taken 2-3 times a day. Some of the more common side effects of this medication include drowsiness, restlessness, and uncontrolled body movement. Thiothixene is only available as a generic medication. Brand name Navane has been discontinued.

• Schizophrenia in people ages 12 years and older

• Drowsiness
• Trouble sleeping
• Restlessness
• Uncontrollable body movement

• Higher risk of death in older adults with dementia-related psychosis
• Difficulty controlling muscle movements (tardive dyskinesia)
• Abnormal and prolonged muscle contractions (dystonia)
• Neuroleptic malignant syndrome (NMS)
• Seizures
• Drowsiness and sleepiness
• Low white blood cell count
• Vision changes
• High prolactin levels

Clozapine (Clozaril) is used to treat schizophrenia. It's an atypical antipsychotic, but it's not a first-choice medication for schizophrenia because it can cause many bothersome side effects, such as drowsiness and dizziness. It can also cause your white blood cell (WBC) count to drop dangerously low and raise your risk for serious infections. As a result, clozapine (Clozaril) is prescribed under a special program called Risk Evaluation and Mitigation Strategies (REMS). In order to pick up your medication at the pharmacy, your provider will ask you to get blood work regularly (weekly to monthly) to make sure your WBC count is at a healthy level.

• Schizophrenia that hasn't responded to other treatments
• Suicidal behavior in people with schizophrenia or schizoaffective disorder

• Increased salivation (Up to 48%)
• Drowsiness (up to 46%)
• Dizziness (up to 27%)
• Fast heart rate (up to 25%)
• Constipation (up to 25%)
• Trouble sleeping (up to 20%)
• Nausea/vomiting (17%)
• High or low blood pressure (up to 13%)
• Fever (up to 13%)
• Headache (10%)
• Heartburn (up to 14%)

• Risk of serious infection (from low white blood cells)
• Low blood pressure, slow heartbeat, and fainting
• Seizures
• Heart problems
• Higher risk of death in older people with dementia-related psychosis
• High blood sugar, high cholesterol, and weight gain
• Severe constipation
• Serious allergic reactions or inflammation problems
• Life-threatening abnormal heart rhythm (QT prolongation)
• Neuroleptic malignant syndrome
• Driving impairment
• Liver problems
• Difficulty controlling body movements
• Not for people with phenylketonuria (dissolvable tablets only)