Key takeaways
Testosterone gel (Testim, AndroGel, Fortesta, Vogelxo) and sildenafil (Viagra) are both prescription medications, but they have different uses. Testosterone gel is a testosterone replacement used to treat low testosterone levels (hypogonadism) in adult males, while sildenafil is a phosphodiesterase-5 (PDE-5) inhibitor used to treat erectile dysfunction (ED). Testosterone gel is applied topically once a day, whereas sildenafil is taken orally as needed, typically about an hour before sexual activity. Testosterone gel is a controlled substance due to its potential for misuse and addiction. Sildenafil is not a controlled substance. Common side effects of testosterone gel include skin irritation and acne, while sildenafil can cause headaches and flushing. Additionally, testosterone gel can interact with blood thinners like warfarin, whereas sildenafil should not be taken with nitrates like isosorbide mononitrate, isosorbide dinitrate, or nitroglycerin.
