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Compare Cialis vs. Stendra

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Tadalafil (Cialis)
Stendra (avanafil)
Tadalafil (Cialis)
Stendra (avanafil)

Summary of Cialis vs. Stendra

Summary for PDE-5 inhibitor
Prescription only

Tadalafil (Cialis) is taken by mouth either as needed before sexual activity or once daily for erectile dysfunction (ED). It's also taken once daily to treat symptoms from an enlarged prostate (benign prostatic hyperplasia, or BPH). Tadalafil (Cialis) is available both as brand-name and generic tablets. Common side effects of this medication include headache and indigestion. Tadalafil (Cialis) does interact with some medications, such as heart and blood pressure medications, and taking them together could lead to very low blood pressure and dizziness.

Summary for PDE-5 inhibitor
Prescription only

Stendra (avanafil) is a phosphodiesterase 5 (PDE5) inhibitor that's used to treat erectile dysfunction (ED). Stendra (avanafil) is taken by mouth as needed, at most once a day. It works best if you take it about 15 to 30 minutes before sexual activity. Some of the more common side effects of Stendra (avanafil) include headache and flushing. Stendra (avanafil) is brand name only and isn't available as a lower-cost generic.

Indications of Cialis vs. Stendra

Indications for
•Erectile dysfunction
•Benign prostatic hyperplasia (BPH)
Indications for
•Erectile dysfunction (ED)

Pros and Cons of Cialis vs. Stendra

Pros and Const for PDE-5 inhibitor
Pros
•One of the first-choice medications for treating ED
•Can be taken either as needed or on a regular basis for those who need it more regularly
•Lasts longer than other medications taken for ED
•Can treat ED and BPH at the same time
•Available as a lower-cost generic
Cons
•Not recommended if you've had a heart attack in the past 3 months, or a stroke or heart failure in the past 6 months
•Can't be used if you've recently taken nitrates like isosorbide mononitrate (Monoket) or nitroglycerin (Nitrostat)
•Takes longer to work compared to some other medications for ED
•Can cause side effects like headache, stomach upset, and back pain
Pros and Const for PDE-5 inhibitor
Pros
•Works faster than some other medications in its class (can be taken 15 minutes before sex)
•Take it only when needed
•Can be taken with or without food
Cons
•Can cause dangerously low blood pressure if you've recently taken nitrates, such as nitroglycerin (Nitrostat)
•Can't take if you have serious heart problems, such as heart attack or stroke in the past 6 months
•Not available as a lower-cost generic

Common Side Effects of Cialis vs. Stendra

Common Side Effects for

Once-daily use of tadalafil (Cialis) (for ED or BPH):

•Headache (3-6%)
•Runny nose, sore throat, and other symptoms of the common cold (3-6%)
•Indigestion (4-5%)
•Stomach upset (3-5%)
•Back pain (3%)

As-needed use of tadalafil (Cialis) (for ED):

•Headache (11-15%)
•Indigestion (4-10%)
•Back pain (3-6%)
Common Side Effects for
•Headache (5-11%)
•Flushing (3-4%)
•Stuffy nose (2-3%)
•Sore throat, runny nose, and other symptoms of a common cold (1-3%)
•Back pain (1-3%)

Warnings of Cialis vs. Stendra

Common Side Effects for
•Heart problems
•Low blood pressure
•Prolonged erection
•Vision changes
•Hearing loss
•Interactions with other medications
Common Side Effects for
•Risk of heart attack or stroke
•Dangerously low blood pressure
•Interactions with other medications
•Avoid drinking alcohol
•Prolonged or painful erection (priapism)
•Vision loss
•Hearing loss

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