Compare
Saxagliptin vs. Sitagliptin

Saxagliptin (Onglyza) is an add-on medication to exercise and a balanced, nutritious diet to improve blood sugar control in adults with Type 2 diabetes. It belongs to the drug class called dipeptidyl peptidase-4 (DPP-4) inhibitors. The saxagliptin (Onglyza) dosage is taken by mouth once daily. Possible side effects include certain infections and headaches. The brand name, Onglyza, is no longer available. But the lower-cost generic version is still available.

• Type 2 diabetes in adults

• Upper respiratory tract infection (8%)
• Urinary tract infection (UTI; 7%)
• Headache (7%)

• Pancreas problems
• Heart failure
• Low blood sugar (hypoglycemia)
• Joint pain
• Large blisters
• Risk of allergic reaction

Januvia (sitagliptin) is a prescription medication that helps lower blood sugar in adults with Type 2 diabetes. It works best when you also follow a balanced diet and exercise regularly. It belongs to the drug class called dipeptidyl peptidase-4 (DPP-4) inhibitors, or gliptins. Januvia (sitagliptin) comes as a tablet you take by mouth once a day. Side effects include stuffy or runny nose and headache. Januvia (sitagliptin) is a brand-name medication only; the generic version isn't available yet.

• Type 2 diabetes in adults

• Runny or stuffy nose and other symptoms of the common cold (5%)

• Inflammation of the pancreas (pancreatitis)
• Risk of heart failure
• Sudden kidney problems
• Low blood sugar when taken with other diabetes medications
• Serious allergic reactions
• Joint pain
• Severe skin reactions