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Rinvoq vs. Cibinqo

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Rinvoq (upadacitinib) and Cibinqo (abrocitinib) are both medications in the Janus kinase (JAK) inhibitor class used to treat inflammatory conditions. They are similar in that they both treat eczema (atopic dermatitis) in people aged 12 and older, but Rinvoq is also used for other conditions like rheumatoid arthritis and ulcerative colitis. Rinvoq is available as an extended-release tablet and an oral solution, while Cibinqo is only available as a tablet. Rinvoq is typically taken once daily, with specific dosing for different conditions, whereas Cibinqo starts at 100 mg once daily and may be increased to 200 mg if needed. Both medications can increase the risk of infections and have warnings for serious side effects like blood clots and cancer. Additionally, Rinvoq can cause side effects such as acne and weight gain, while Cibinqo commonly causes nausea and cold symptoms. Rinvoq should not be taken with grapefruit, and Cibinqo should be avoided with certain blood thinners. Neither medication is considered safe during pregnancy or breastfeeding.

Rinvoq

(upadacitinib)

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Cibinqo

(abrocitinib)

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Summary for Rinvoq

Prescription only

Rinvoq (upadacitinib) is a Janus kinase (JAK) inhibitor. It's used to treat certain inflammatory conditions, such as rheumatoid arthritis (RA), ulcerative colitis (UC), and eczema (atopic dermatitis). But it's not a first-choice option and typically only prescribed when other treatments haven't worked well. Rinvoq (upadacitinib) is taken by mouth, usually once daily. It's available as an extended-release tablet (Rinvoq) and an oral solution (Rinvoq LQ), but the two formulations aren't interchangeable. Side effects include a higher risk of infections, acne, and nausea.

Indications for Rinvoq

Moderate-to-severe inflammatory conditions in which other treatments haven't worked:

Pros and Cons for Rinvoq

Pros

  • Can treat many different inflammatory conditions
  • Available as a tablet and a liquid
  • The tablet only needs to be taken once a day

Cons

  • Can raise risk for infections
  • Not the best option for people with severe liver or kidney problems
  • Not safe for use during pregnancy

Common Side Effects for Rinvoq

Note: Side effects listed were reported by people who took Rinvoq for eczema.

Warnings for Rinvoq

  • Serious infections
  • Possible higher risk of death for people with rheumatoid arthritis
  • Risk of cancer
  • Possible risk of heart attack, stroke, and other blood clots
  • Severe allergic reaction
  • Stomach and gut tears
  • Abnormal lab results (e.g., blood cell counts, cholesterol levels)
  • Possible harm to unborn babies
  • Medication in stool

Summary for Cibinqo

Prescription only

Cibinqo (abrocitinib) is used to treat moderate-to-severe atopic dermatitis (also known as eczema) in adults and children ages 12 years and older. It's taken by mouth, typically once daily. Cibinqo (abrocitinib) isn't a first-choice option for this condition because it has a FDA black box warning for the potential to cause serious side effects, such as cancer and infections. Some of the more common side effects of this medication include nausea, cold symptoms, and headaches.

Indications for Cibinqo

  • Moderate-to-severe atopic dermatitis (eczema) in people age 12 years and older who didn't respond to other treatments

Pros and Cons for Cibinqo

Pros

  • Works well at treating eczema for both adults and children age 12 years and older
  • Taken once per day by mouth
  • Can be used along with topical treatments for eczema
  • Can be taken with or without food

Cons

  • Raises your risk for serious side effects, such as blood clots and infections
  • Not a good choice for people who have trouble swallowing because the tablets can't crushed and there isn't a liquid version available
  • Not safe for people with serious liver or kidney problems
  • Safety in pregnancy or breastfeeding isn't clear

Common Side Effects for Cibinqo

  • Nausea (6-15%)
  • Common cold (9-12%)
  • Headache (6-8%)
  • Acne (2-5%)

Warnings for Cibinqo

  • Serious infections
  • Possible higher risk of death
  • Possible risk of cancer
  • Risk of heart attack, stroke, and other blood clots
  • Low blood cell counts
  • High cholesterol

Prices with our coupons for Rinvoq vs. Cibinqo

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Rinvoq30 tablets / 15mg
$6,244.67$8,869.21
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Cibinqo30 tablets / 100mg
$5,690.91$8,058.31
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