Key takeaways
Brexpiprazole (Rexulti) and bupropion hydrochloride (Wellbutrin XL, Wellbutrin SR) are both medications used to treat depression, but they belong to different medication classes. Brexpiprazole is an atypical antipsychotic, while bupropion is an atypical antidepressant. Brexpiprazole is also approved for schizophrenia and dementia-related agitation from Alzheimer's disease, whereas bupropion is used for seasonal affective disorder (SAD) in addition to depression. Brexpiprazole is typically taken once daily, while bupropion can be taken in different forms, either once daily or multiple times a day, depending on the formulation. Both medications are avaiable in a branded version and a lower-cost generic. Common side effects of brexpiprazole include restlessness, weight gain, and headaches, while bupropion may cause dry mouth, nausea, and trouble sleeping. Brexpiprazole can cause serious side effects like tardive dyskinesia and neuroleptic malignant syndrome, while bupropion carries a risk of seizures, especially in people with a history of seizures or eating disorders.
