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Rexulti vs. Abilify

Rexulti (brexpiprazole) is an atypical antipsychotic used to treat depression and schizophrenia. It can also help manage dementia-related agitation from Alzheimer's disease. The medication works by balancing chemicals in your brain to regulate your mood. Rexulti (brexpiprazole) comes as a tablet you take by mouth, usually once a day. Common side effects include weight gain, sleepiness, and dizziness. Although generic versions have been approved, they aren't yet available in pharmacies.

• Add-on treatment for depression in adults
• Schizophrenia in adults and teens 13 years and older
• Dementia-related agitation from Alzheimer's disease

Depression

• Fidgeting (9%)
• Weight gain (7%)
• Headache (7%)
• Sleepiness (5%)

Schizophrenia

• Fidgeting (6%)

Dementia-related agitation

• Headache (8%)

• Higher risk of death in older adults with dementia-related psychosis
• Suicidal thoughts and behaviors
• Neuroleptic malignant syndrome (NMS)
• Uncontrolled body movements (tardive dyskinesia)
• High blood sugar, high cholesterol, and weight gain
• Impulse control problems
• Low white blood cell count
• Falls and fainting
• Seizures
• Trouble controlling body temperature
• Difficulty swallowing
• Problems with thinking and movement

Aripiprazole (Abilify) is an atypical antipsychotic used to treat different mental health conditions, such as schizophrenia and bipolar I disorder. It works by balancing certain chemicals in the brain to help control thoughts, mood, and behaviors. It's available in many dosage forms, including an oral tablet, solution, and an orally disintegrating tablet (ODT) that can be used in adults and children as young as 6 years old for certain conditions. Common side effects include headache, movement problems, and sleep problems.

• Schizophrenia
• Tourette syndrome in children
• Bipolar I disorder
• Depression (add-on treatment)
• Irritability associated with autistic disorder in children

• Headache (27%)
• Agitation (19%)
• Trouble sleeping (18%)
• Anxiety (17%)
• Nausea (15%)
• Vomiting (11%)
• Constipation (11%)
• Dizziness (10%)
• Trouble staying still (10%)

Note: Side effects were reported by adults who took aripiprazole in clinical studies for schizophrenia and bipolar disorder.

• Higher risk of death in older adults with dementia-related psychosis
• Neuroleptic malignant syndrome
• High blood sugar, high cholesterol, and weight gain
• Difficulty controlling movements
• Changes in blood pressure and higher risk of falls
• Risk of infection (from low white blood cell count)
• Difficulty concentrating and extreme sleepiness
• Seizures
• Impulse-control problems