Rexulti vs. Abilify for Depression and Schizophrenia: Important Differences and Potential Risks.

Rexulti

(brexpiprazole)

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Aripiprazole

(Abilify)

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Summary for Rexulti

Prescription only

Rexulti (brexpiprazole) is an atypical antipsychotic used to treat depression and schizophrenia. It can also help manage dementia-related agitation from Alzheimer's disease. The medication works by balancing chemicals in your brain to regulate your mood. Rexulti (brexpiprazole) comes as a tablet you take by mouth, usually once a day. Common side effects include weight gain, sleepiness, and dizziness. Although generic versions have been approved, they aren't yet available in pharmacies.

Indications for Rexulti

Add-on treatment for depression in adults
Schizophrenia in adults and teens 13 years and older
Dementia-related agitation from Alzheimer's disease

Pros and Cons for Rexulti

Pros

Only need to take once a day
Less likely to cause weight gain compared to older antipsychotics
Available in many strengths

Cons

Can take a couple of months to fully work
Interacts with many medications
Not known if safe in pregnancy

Common Side Effects for Rexulti

Depression

Fidgeting (9%)
Weight gain (7%)
Headache (7%)
Sleepiness (5%)

Schizophrenia

Fidgeting (6%)

Dementia-related agitation

Headache (8%)

Warnings for Rexulti

Higher risk of death in older adults with dementia-related psychosis
Suicidal thoughts and behaviors
Neuroleptic malignant syndrome (NMS)
Uncontrolled body movements (tardive dyskinesia)
High blood sugar, high cholesterol, and weight gain
Impulse control problems
Low white blood cell count
Falls and fainting
Seizures
Trouble controlling body temperature
Difficulty swallowing
Problems with thinking and movement

Summary for Abilify

Prescription only

Aripiprazole (Abilify) is used to treat different mental health conditions. This includes schizophrenia, depression, and bipolar I disorder. It belongs to a drug class called atypical antipsychotics. Aripiprazole (Abilify) comes in several forms that are taken by mouth: a tablet, oral solution, and orally disintegrating tablet (ODT). The approved age depends on the condition being treated. Some uses are for adults only, while others are approved for children as young as 6 years old. Common side effects include headache and movement problems.

Indications for Abilify

Schizophrenia
Bipolar I disorder
Depression - add-on treatment for adults
Irritability related to autistic disorder - for children
Tourette syndrome - for children

Pros and Cons for Abilify

Pros

Taken once a day
Available as a liquid or dissolvable tablet for people who have trouble swallowing pills
Lower risk of weight gain than many other antipsychotics

Cons

Can cause restlessness or make it hard to sit still
Risk of movement problems that can become permanent
Can raise blood sugar and cholesterol

Common Side Effects for Abilify

Headache (27%)
Agitation (19%)
Trouble sleeping (18%)
Anxiety (17%)
Nausea (15%)
Vomiting (11%)
Constipation (11%)
Dizziness (10%)
Trouble staying still (10%)

Warnings for Abilify

Higher risk of death or stroke in older adults with dementia-related psychosis
Risk of suicidal thoughts and behaviors
Neuroleptic malignant syndrome
Trouble controlling muscle movements (tardive dyskinesia)
High blood sugar, high cholesterol, and weight gain
Strong urges that are hard to control
Low blood pressure and risk of falls
Low white blood cell count (leading to risk of infection)
Seizures
Trouble concentrating and sleepiness
Trouble swallowing and possible complications
Risk for people with phenylketonuria (PKU) - orally disintegrating tablets only

Prices with our coupons for Rexulti vs. Abilify

Rexulti30 tablets / 1mg

$1,499.59$1,943.66

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Aripiprazole30 tablets / 5mg

$13.44$47.16

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Rexulti vs. Abilify

Rexulti

Aripiprazole

Summary for Rexulti

Indications for Rexulti

Pros and Cons for Rexulti

Pros

Cons

Common Side Effects for Rexulti

Warnings for Rexulti

Summary for Abilify

Indications for Abilify

Pros and Cons for Abilify

Pros

Cons

Common Side Effects for Abilify

Warnings for Abilify

Prices with our coupons for Rexulti vs. Abilify

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Rexulti

Aripiprazole

Summary for Rexulti

Indications for Rexulti

Pros and Cons for Rexulti

Pros

Cons

Common Side Effects for Rexulti

Warnings for Rexulti

Summary for Abilify

Indications for Abilify

Pros and Cons for Abilify

Pros

Cons

Common Side Effects for Abilify

Warnings for Abilify