Rexulti vs. Abilify for Depression and Schizophrenia: Important Differences and Potential Risks.

Rexulti

(brexpiprazole)

Aripiprazole

(Abilify)

Summary for Rexulti

Prescription only

Rexulti (brexpiprazole) is an atypical antipsychotic used to treat depression and schizophrenia. It can also help manage dementia-related agitation from Alzheimer's disease. The medication works by balancing chemicals in your brain to regulate your mood. Rexulti (brexpiprazole) comes as a tablet you take by mouth, usually once a day. Common side effects include weight gain, sleepiness, and dizziness. Although generic versions have been approved, they aren't yet available in pharmacies.

Indications for Rexulti

Add-on treatment for depression in adults
Schizophrenia in adults and teens 13 years and older
Dementia-related agitation from Alzheimer's disease

Pros and Cons for Rexulti

Pros

Only need to take once a day
Less likely to cause weight gain compared to older antipsychotics
Available in many strengths

Cons

Can take a couple of months to fully work
Interacts with many medications
Not known if safe in pregnancy

Common Side Effects for Rexulti

Depression

Fidgeting (9%)
Weight gain (7%)
Headache (7%)
Sleepiness (5%)

Schizophrenia

Fidgeting (6%)

Dementia-related agitation

Headache (8%)

Warnings for Rexulti

Higher risk of death in older adults with dementia-related psychosis
Suicidal thoughts and behaviors
Neuroleptic malignant syndrome (NMS)
Uncontrolled body movements (tardive dyskinesia)
High blood sugar, high cholesterol, and weight gain
Impulse control problems
Low white blood cell count
Falls and fainting
Seizures
Trouble controlling body temperature
Difficulty swallowing
Problems with thinking and movement

Summary for Abilify

Prescription only

Aripiprazole (Abilify) is an atypical antipsychotic used to treat different mental health conditions, such as schizophrenia and bipolar I disorder. It works by balancing certain chemicals in the brain to help control thoughts, mood, and behaviors. It's available in many dosage forms, including an oral tablet, solution, and an orally disintegrating tablet (ODT) that can be used in adults and children as young as 6 years old for certain conditions. Common side effects include headache, movement problems, and sleep problems.

Indications for Abilify

Schizophrenia
Tourette syndrome in children
Bipolar I disorder
Depression (add-on treatment)
Irritability associated with autistic disorder in children

Pros and Cons for Abilify

Pros

Only taken once a day
Available in a liquid and dissolvable tablet for people who have trouble swallowing pills
Less likely to cause weight gain than most other antipsychotics
Available as a lower-cost generic

Cons

Can make you feel restless
Risk of movement problems that can be permanent
Can raise blood sugar and cholesterol
Can take several weeks to see the full effects

Common Side Effects for Abilify

Headache (27%)
Agitation (19%)
Trouble sleeping (18%)
Anxiety (17%)
Nausea (15%)
Vomiting (11%)
Constipation (11%)
Dizziness (10%)
Trouble staying still (10%)

Note: Side effects were reported by adults who took aripiprazole in clinical studies for schizophrenia and bipolar disorder.

Warnings for Abilify

Higher risk of death in older adults with dementia-related psychosis
Neuroleptic malignant syndrome
High blood sugar, high cholesterol, and weight gain
Difficulty controlling movements
Changes in blood pressure and higher risk of falls
Risk of infection (from low white blood cell count)
Difficulty concentrating and extreme sleepiness
Seizures
Impulse-control problems

Prices with our coupons for Rexulti vs. Abilify

Rexulti30 tablets / 1mg

$1,494.82$1,943.67

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Aripiprazole30 tablets / 5mg

$13.16$439.63

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Rexulti vs. Abilify

Rexulti

Aripiprazole

Summary for Rexulti

Indications for Rexulti

Pros and Cons for Rexulti

Pros

Cons

Common Side Effects for Rexulti

Warnings for Rexulti

Summary for Abilify

Indications for Abilify

Pros and Cons for Abilify

Pros

Cons

Common Side Effects for Abilify

Warnings for Abilify

Prices with our coupons for Rexulti vs. Abilify

Compare other Depression and Schizophrenia drugs

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Rexulti

Aripiprazole

Summary for Rexulti

Indications for Rexulti

Pros and Cons for Rexulti

Pros

Cons

Common Side Effects for Rexulti

Warnings for Rexulti

Summary for Abilify

Indications for Abilify

Pros and Cons for Abilify

Pros

Cons

Common Side Effects for Abilify

Warnings for Abilify