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Compare Omvoh vs. Skyrizi

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Omvoh (mirikizumab) and Skyrizi (risankizumab) are both medications used to treat inflammatory conditions, and they work by blocking interleukin-23 (IL-23) to reduce inflammation. Omvoh is specifically FDA-approved for moderate-to-severe ulcerative colitis in adults, while Skyrizi is approved for that condition as well as moderate-to-severe plaque psoriasis, psoriatic arthritis, and Crohn's disease. Omvoh is administered initially as intravenous infusions for the first three doses, followed by monthly subcutaneous (under the skin) injections. In contrast, Skyrizi starts with intravenous infusions for ulcerative colitis and then switches to subcutaneous injections every 2 or 3 months. For subcutaneous injection forms, Omvoh is available as prefilled pens, while Skyrizi offers prefilled syringes, pens, and an On-Body Injector. Both medications can cause side effects like injection site reactions, joint pain, and increased risk of infections. Additionally, both medications require caution with live vaccines due to their immunosuppressive effects.

  • Omvoh (mirikizumab)
    Skyrizi (risankizumab)
  • Omvoh (mirikizumab)
    Skyrizi (risankizumab)

  • Summary of Omvoh vs. Skyrizi

    Summary for Interleukin-23 antagonist
    Prescription only

    Omvoh (mirikizumab or mirikizumab-mrkz) helps treat ulcerative colitis and Crohn's disease in adults. It's a biologic known as an interleukin-23 antagonist. It works to help lower inflammation in the gut. When you first start, you'll get your first three doses as an infusion through the vein (IV) once a month at a clinic. After that, you (or your caregiver) can inject the rest of your doses under the skin every month at home. Side effects include joint pain and upper respiratory tract infections. Omvoh (mirikizumab) is available as a brand-name medication only.

    Summary for Interleukin antagonist
    Prescription only

    Skyrizi (risankizumab or risankizumab-rzaa) is an injection used to treat different inflammatory conditions in adults. This includes plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It belongs to the drug class called interleukin antagonists. It works to lower inflammation and relieve symptoms. After the first few doses, you usually get the Skyrizi (risankizumab) injection every 2 or 3 months. This medication can raise your risk of infection as a side effect.

  • Indications of Omvoh vs. Skyrizi

    Indications for
    •Moderate-to-severe ulcerative colitis in adults
    •Moderate-to-severe Crohn's disease in adults
    Indications for
    •Moderate-to-severe plaque psoriasis in adults
    •Psoriatic arthritis in adults
    •Moderate-to-severe Crohn's disease in adults
    •Moderate-to-severe ulcerative colitis in adults

  • Pros and Cons of Omvoh vs. Skyrizi

    Pros and Const for Interleukin-23 antagonist
    Pros
    •Given once a month
    •Available as ready-to-inject prefilled pens and syringes after the first three infusions
    •Can inject maintenance doses at home with proper training
    •Can improve symptoms when other treatments haven't worked well
    Cons
    •Injection only
    •Must get the first few doses as IV infusions from a healthcare professional
    •Can cause injection site reactions like redness, pain, and itchiness
    •Can raise your risk of getting sick more easily
    Pros and Const for Interleukin antagonist
    Pros
    •Given every 2 or 3 months after a couple of starter doses (depends on your condition)
    •Can give injections under the skin at home after you get trained
    Cons
    •Must be given as an injection
    •Not approved for children

  • Common Side Effects of Omvoh vs. Skyrizi

    Common Side Effects for

    Induction with IV infusions

    •Upper respiratory tract infections (8%)
    •Joint pain (2%)

    Maintenance with under-the-skin injections

    •Upper respiratory tract infections (14%)
    •Injection site reaction (e.g., redness, pain; 9%)
    •Joint pain (7%)
    Common Side Effects for
    •Upper respiratory infections (13%)
    •Headache (4%)
    •Tiredness (3%)

  • Warnings of Omvoh vs. Skyrizi

    Common Side Effects for
    •Allergic reactions
    •Risk of infection
    •Liver injury
    •Avoid live vaccines
    Common Side Effects for
    •Allergic reaction
    •Risk of infection
    •Rare case of liver injury
    •Caution when getting vaccines

  • Prices with our coupons for Omvoh vs. Skyrizi

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    Learn more about Skyrizi

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