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Lisinopril vs. Zestoretic

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Lisinopril (Zestril) and Zestoretic (lisinopril/hydrochlorothiazide) are both medications used to lower blood pressure, but they have some key differences. Lisinopril (Zestril) is an ACE inhibitor that works by relaxing your blood vessels. It can also treat heart failure and reduce the risk of death after a heart attack. It's available as a tablet and a liquid, and common side effects include cough, dizziness, and headache. On the other hand, Zestoretic combines lisinopril with hydrochlorothiazide, a diuretic that helps remove extra water and certain electrolytes from your body. This combination can cause you to urinate more often and may lead to changes in electrolyte levels, blood sugar, and cholesterol. Both medications are taken once daily and are not safe for use during pregnancy or breastfeeding. While both medications are available in lower-cost generic forms, Zestoretic combines two medications into one convenient pill.

Lisinopril

(Zestril)

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Zestoretic

(lisinopril / hydrochlorothiazide)

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Summary for Lisinopril

Prescription only

Lisinopril (Zestril) is an angiotensin-converting enzyme inhibitor, or ACE inhibitor. It's used to treat high blood pressure in people 6 years and older. In adults, it's also approved to manage heart failure and to lower the risk of death after a heart attack. Lisinopril (Zestril) comes as a tablet that's taken by mouth once daily. There's also an oral solution available under the brand name Qbrelis. Some side effects include dizziness, cough, and headache.

Indications for Lisinopril

Pros and Cons for Lisinopril

Pros

  • Taken by mouth once per day
  • A first-choice medication for high blood pressure
  • Also helpful for heart failure and after a heart attack
  • Okay for children as young as 6 years old to take to treat high blood pressure

Cons

Common Side Effects for Lisinopril

  • Dizziness (up to 19%)
  • Low blood pressure (up to 11%)
  • Higher creatinine levels (up to 10%)

Warnings for Lisinopril

  • Harm to an unborn baby
  • Angioedema (swelling)
  • Low blood pressure
  • Possible worsening of kidney problems
  • High potassium levels
  • Liver problems

Summary for Zestoretic

Prescription only

Zestoretic is a combination blood pressure medication for adults. It contains lisinopril (an angiotensin-converting enzyme (ACE) inhibitor) and hydrochlorothiazide (a thiazide diuretic). It comes as a tablet that's taken by mouth once per day. Your prescriber will determine your dosage based on how high your blood pressure is and if you're taking other blood pressure medications. Some of the more common side effects it can cause include dizziness, headache, and cough. Zestoretic (lisinopril / hydrochlorothiazide) is available as a generic.

Indications for Zestoretic

Pros and Cons for Zestoretic

Pros

  • Combines two medications in one pill
  • Taken by mouth
  • Taken once daily

Cons

  • Can make you urinate more often
  • Might not be appropriate for someone with a sulfa allergy
  • Shouldn't take during pregnancy or breastfeeding

Common Side Effects for Zestoretic

  • Dizziness (8%)
  • Headache (5%)
  • Cough (4%)
  • Extreme tiredness (4%)
  • Feeling lightheaded when standing after sitting or lying down (3%)

Warnings for Zestoretic

  • Not for use during pregnancy
  • Angioedema (swelling)
  • Low blood pressure
  • Kidney damage
  • Changes in electrolyte, blood sugar, and cholesterol levels
  • Vision problems
  • Lupus

Prices with our coupons for Lisinopril vs. Zestoretic

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Lisinopril30 tablets / 20mg
$7.79$13.70
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Lisinopril/HCTZ90 tablets / 20mg/12.5mg
$17.33$62.43
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