Key takeaways
Invega (paliperidone) and Rexulti (brexpiprazole) are both atypical antipsychotics, but they have some key differences. Invega is available in both brand and generic forms and is used to treat schizophrenia and schizoaffective disorder. It is taken once daily as an extended-release tablet. Rexulti, also taken once daily, is available only as a brand-name medication and is used to treat schizophrenia, as an add-on for depression, and dementia-related agitation from Alzheimer's disease. Invega can cause side effects like drowsiness and uncontrolled muscle movements, while Rexulti may cause restlessness and moderate weight gain. Additionally, Invega has long-acting injection forms, whereas Rexulti does not. Both medications can cause weight gain, but Rexulti is less likely to cause high cholesterol or high blood sugar compared to other antipsychotics.
