Key takeaways
Hydralazine and isosorbide dinitrate (Isordil) are both vasodilators, but they are used for different conditions. Hydralazine is primarily used to lower blood pressure, especially when other medications aren't effective. It is available as a lower-cost generic tablet and needs to be taken multiple times a day. Common side effects include headache, stomach upset, and a fast heart rate. On the other hand, isosorbide dinitrate is used to relieve chest pain caused by angina. It is available in both short-acting and long-acting forms, with the short-acting tablet being less expensive. Isosorbide dinitrate can cause headaches and dizziness, and it must be taken on a specific schedule to prevent tolerance. Unlike hydralazine, isosorbide dinitrate interacts with erectile dysfunction medications and alcohol, which can dangerously lower blood pressure.
