Compare Isordil vs. Nitrostat

Isosorbide dinitrate (Isordil) and nitroglycerin (Nitrostat) are both nitrate vasodilators used to treat chest pain (angina), but they have some key differences. Isosorbide dinitrate is available in both short-acting tablets and long-acting capsules, and it works slowly to prevent chest pain. In contrast, nitroglycerin is a fast-acting medication that you place under your tongue or against your cheek, and it starts working within 1 to 3 minutes to relieve chest pain. Isosorbide dinitrate needs to be taken on a strict schedule to avoid tolerance, while nitroglycerin is used as needed at the first sign of chest pain or before activities that might cause it. Both medications can cause headaches and low blood pressure, but nitroglycerin can also cause a tingling or burning feeling in the mouth. Additionally, nitroglycerin is available in a lower-cost generic form, whereas the long-acting capsule form of isosorbide dinitrate is only available as a brand-name medication.