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Dicyclomine vs. Linzess

Dicyclomine, also known by its brand name Bentyl, is an anticholinergic medication that's used to treat spasms of the muscles in the stomach and intestines in adults with irritable bowel syndrome (IBS). This medication is available as generic tablets, capsules, and liquid that are taken by mouth four times daily. There's also an injection form of dicyclomine that's available as brand name and generic; it's injected into the muscle for people who can't take pills by mouth. Common side effects include dizziness, dry mouth, and blurry vision.

• Irritable bowel syndrome (IBS)

• Dizziness (40%)
• Dry mouth (33%)
• Blurred vision (27%)
• Nausea (14%)

• Faster heart rate (caution in people with heart conditions)
• Changes in mood, thoughts, or behaviors
• Changes to bodily functions
• Muscle weakness (caution in people with myasthenia gravis)
• Strong caution in people with certain gut problems
• Trouble urinating (caution in people with prostate problems)

Linzess (linaclotide) is approved for people 7 years and older with constipation from irritable bowel syndrome (IBS-C). It's also for adults with long-lasting or chronic constipation from unknown reasons. Children 6 years and older with functional constipation can take this medication as well. Linzess (linaclotide) belongs to a drug class called guanylate cyclase-C agonists. It's a capsule that's taken by mouth once a day. But diarrhea is a common side effect. This medication is currently brand name only; there's no generic version yet.

• Irritable bowel syndrome with constipation (IBS-C) in people 7 years and older
• Chronic idiopathic constipation (CIC) in adults
• Functional constipation (FC) in children 6 years and older

Adults:

• Diarrhea
• Stomach pain
• Having gas
• Bloating and feeling full in the belly

Children:

• Diarrhea

• Not for children under 2 years old because of risk of serious dehydration
• Severe diarrhea