Key takeaways
Divalproex (Depakote) and lithium (Lithobid) are both used to treat bipolar disorder, but they belong to different medication classes. Divalproex is an antiepileptic, while lithium is an antimanic. Divalproex is also used to treat seizures and prevent migraines, whereas lithium is specifically for treating manic episodes and long-term maintenance of bipolar disorder. Divalproex comes in various forms, including delayed-release tablets, extended-release tablets, and sprinkle capsules, and is typically taken once or twice daily. In contrast, lithium is available as instant-release pills, oral liquid, and extended-release tablets, and is usually taken 2 to 3 times a day. Both medications require regular blood tests to monitor their levels and potential side effects, due to a risk of toxicity if levels become too high. Common side effects of divalproex include nausea, sleepiness, and dizziness. Lithium can also cause nausea, sleepiness, and dizziness, as well as increased thirst, and frequent urination. Neither medication is recommended during pregnancy due to potential risks to the fetus.
