Key takeaways
Anastrozole (Arimidex) and clomiphene (Clomid) are both oral medications that affect estrogen levels in the body, but they are used for different purposes. Anastrozole is an aromatase inhibitor used to treat breast cancer in postmenopausal women by lowering estrogen levels, which can help slow the growth of certain cancer cells. Clomiphene, on the other hand, is a selective estrogen receptor modulator (SERM) used to treat female infertility by tricking the body into thinking estrogen levels are low, which stimulates ovulation. Anastrozole is typically taken as a 1 mg tablet daily, while clomiphene is taken as a 50 mg tablet once a day for 5 days during the menstrual cycle. Both medications are available as a lower-cost generic. Anastrozole can cause side effects like hot flashes and bone weakening, while clomiphene can cause side effects like hot flashes and stomach pain. Anastrozole should not be taken with medications containing estrogen, and clomiphene should be avoided if you have liver problems, certain thyroid problems, or are pregnant.
