What Are the Best Prescription Weight-Loss Pills?
There are several weight-loss medications on the market, but which one is the best fit for you? Compare popular weight-loss pills and see common FAQs.
Alli
Used for Weight loss
Used for Weight loss
Orlistat is a medication that works alongside diet and exercise to increase weight loss in people who are overweight or obese. It needs to be taken three times a day and is available with a prescription in a higher dose (Xenical) or over the counter in a lower dose (Alli).
What is Orlistat?
What is Orlistat used for?
Xenical (orlistat):
- Obesty management in adults with a body mass index (BMI) of:
- 30 kg/m2 or greater or
- 27 kg/m2 or greater and at least one weight-related condition (e.g., high blood pressure, type 2 diabetes, or high cholesterol)
- Weight loss in adults when combined with a lower-calorie and low-fat diet
How Orlistat works
Orlistat is a lipase inhibitor. It inhibits (blocks) proteins called lipases in your stomach and pancreas that normally help to digest fats in your diet. By blocking lipase, orlistat helps your body absorb less fat.
Drug facts
| Common Brands | Xenical, Alli |
|---|---|
| Drug Class | Lipase inhibitor |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription or over-the-counter |
Side effects of Orlistat
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
Xenical (orlistat):
- Oily spotting on underwear (4-27%)
- Gas with anal discharge (2-24%)
- Urge to have a bowel movement (3-22%)
- Fatty or oily stool (6-20%)
- Having more bowel movements (3-11%)
- Difficulty controlling bowel movements (2-8%)
- Gas with oily spotting
- Loose stools
- More frequent stools that are hard to control
Less Common Side Effects
Xenical (orlistat):
- Headache
- Stomach pain or discomfort
- Back pain
- Period (menstrual) changes
- Nausea
- Rectal pain
Orlistat serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Liver injury: upper right stomach pain or discomfort, dark-colored urine, pale-colored stools, yellowing of the skin or eyes, loss of appetite, itching
- Kidney problems or kidney stones: pain on the sides of your lower back, blood in your urine, nausea or vomiting, or urine that smells bad, looks cloudy
- Severe stomach pain or stomach pain that won't go away
- More frequent or worse seizures
More on Orlistat side effects
The following Orlistat side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Bladder pain
body aches
chills
difficulty with breathing
ear congestion
general feeling of discomfort or illness
headache
loss of appetite
loss of voice
lower back or side pain
muscle aches and pains
shivering
sweating
trouble sleeping
unusual tiredness or weakness
vomiting
Rare
Bloody or cloudy urine
change in hearing
contagious diarrhea
dark urine
difficult or painful urination
fast heartbeat
frequent urge to urinate
general tiredness and weakness
hoarseness
irritation
joint pain, stiffness, or swelling
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
noisy breathing
pain in the ears
rash
redness of the skin
shortness of breath
skin blisters
swelling of the eyelids, face, lips, hands, or feet
troubled swallowing
upper right abdominal or stomach pain
yellow eyes and skin
Incidence not known
blurred vision
cold sweats
coma
confusion
cool, pale skin
dizziness
dry skin and hair
feeling cold
hoarseness or husky voice
increased hunger
indigestion
loss of appetite
muscle cramps and stiffness
nervousness
nightmares
pains in the stomach, side, or abdomen, possibly radiating to the back
seizures
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Get your GoodRx coupon
$62.97
GoodRx discount
$52.98
Pros and cons of Orlistat
Pros
- Works well to block a portion of the fat you eat
- Xenical is approved for people ages 12 years and older.
- Available in both prescription and over-the-counter forms
Cons
- Still need to maintain a healthy diet and exercise routine
- Must remember to take with each fat-containing meal
- Only available as a brand medication so it can be expensive
Pharmacist tips for Orlistat
- Take orlistat with each main meal that has fat in it or up to 1 hour after your meal.
- Orlistat can affect your body's absorption of certain vitamins. It's recommended that you take a daily multivitamin while taking this medication. If you're taking Xenical, take the multivitamin at least 2 hours before or after you take Xenical, such as at bedtime. If you're taking Alli, take the multivitamin once a day at bedtime.
- Orlistat can affect the way other medications work. Similarly, other medications can affect the way orlistat works. Tell your provider and pharmacist about all the medications and supplements you're taking before starting orlistat.
- If you've had an organ transplant, don't take Alli. Alli can interfere with the medications used to prevent transplant rejection.
- For the best results, make sure to maintain a healthy diet and exercise routine while taking orlistat. If you're taking Xenical, your diet should have no more than 30% of its calories from fat. Taking orlistat with a meal containing more than 30% fat can cause more side effects.
Risks and warnings for Orlistat
Orlistat can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Medication interactions
- Risk factors: Taking orlistat with certain medications
Orlistat can affect the way other medications work. Similarly, other medications can affect the way orlistat works. Examples of these medications include cyclosporine, levothyroxine, warfarin, amiodarone, anti-seizure medications, and HIV medications. Tell your provider and pharmacist about all the medications and supplements you're taking before starting orlistat. They can help you make sure you're taking all of your medications at the correct times to get the most out of each medication.
Liver injury
- Risk factors: History of liver problems
Orlistat can sometimes cause serious liver injury. Your provider will likely check your liver before starting you on orlistat. If you have a history of liver problems, your provider may check your liver tests more often. While taking this medication, if you experience abdominal pain, dark-colored urine, pale-colored stools, or yellowing of the skin or eyes, loss of appetite, or itching, get medical help right away.
Higher oxalate levels in the urine
- Risk factors: History of kidney stones
Although rare, orlistat can raise the amount of oxalate in your urine. If there's too much oxalate in the urine, it can bind to calcium and cause kidney stones. Your provider will make sure to check your kidney function before starting you on orlistat and throughout treatment to make sure you don't develop kidney injury or kidney stones. Tell your provider right away if you develop pain on the sides of your lower back, blood in your urine, nausea or vomiting, or urine that smells bad or looks cloudy.
Gallstones
Losing weight can sometimes raise the risk of gallstones. In the clinical studies for orlistat, about 3% of people who took the medication to prevent diabetes developed gallstones compared to 2% of people who took the placebo.
Other causes of obesity
Your provider will want to rule out all causes of obesity before starting you on treatment with orlistat. If you have hypothyroidism, for example, your provider can prescribe you a thyroid medication rather than a weight loss drug like orlistat.
Orlistat dosage
The average cost for 90 capsules of 60mg of Orlistat is $52.98 with a free GoodRx coupon. This is 15.86% off the average retail price of $62.97. 
Capsule
Capsule| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 60mg | 90 capsules | $52.98 | $0.59 |
Typical dosage for Orlistat
- Xenical (orlistat): The typical dose is 120 mg by mouth three times a day with each main meal containing fat.
- Alli (orlistat): The typical dose is 60 mg by mouth three times a day with each meal that contains fat. Don't take more than 180 mg per day.
Interactions between Orlistat and other drugs
Orlistat may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Orlistat. Please note that only the generic name of each medication is listed below.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Abacavir
- Acenocoumarol
- Apixaban
- Ardeparin
- Argatroban
- Atazanavir
- Bivalirudin
- Carbamazepine
- Certoparin
- Clobazam
- Clonazepam
- Clorazepate
- Cobicistat
- Cyclosporine
- Dabigatran Etexilate
- Dalteparin
- Danaparoid
- Darunavir
- Desirudin
- Diazepam
- Didanosine
- Edoxaban
- Efavirenz
- Elvitegravir
- Emtricitabine
- Enoxaparin
- Eslicarbazepine Acetate
- Ethosuximide
- Ethotoin
- Etravirine
- Ezogabine
- Felbamate
- Fondaparinux
- Fosamprenavir
- Fosphenytoin
- Gabapentin
- Gabapentin Enacarbil
- Heparin
- Indinavir
- Lacosamide
- Lamivudine
- Lamotrigine
- Lepirudin
- Levetiracetam
- Lopinavir
- Lorazepam
- Methsuximide
- Midazolam
- Nadroparin
- Nelfinavir
- Nevirapine
- Oxcarbazepine
- Parnaparin
- Perampanel
- Phenindione
- Phenobarbital
- Phenprocoumon
- Phenytoin
- Piracetam
- Pregabalin
- Primidone
- Protein C
- Raltegravir
- Reviparin
- Rilpivirine
- Ritonavir
- Rivaroxaban
- Rufinamide
- Saquinavir
- Stavudine
- Stiripentol
- Telaprevir
- Tenofovir
- Tiagabine
- Tinzaparin
- Tipranavir
- Topiramate
- Triheptanoin
- Valproic Acid
- Vigabatrin
- Warfarin
- Zidovudine
- Zonisamide
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Linoleic Acid
How much does Orlistat cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Alli (brand)
$52.98
Orlistat contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Orlistat will not be safe for you to take.
Xenical (orlistat):
- Currently pregnant
- Chronic malabsorption syndrome
- Cholestasis (a problem with bile flow from the liver)
- History of organ transplant
- Take cyclosporine (Sandimmune)
- Problems absorbing food
- Not overweight
What are alternatives to Orlistat?
There are a number of medications that your doctor can prescribe in place of Orlistat. Compare a few possible alternatives below.
News about Orlistat
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Orlistat images
