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Adbry

Tralokinumab-Ldrm
Used for Eczema
Used for Eczema

Adbry (tralokinumab or tralokinumab-ldrm) is biologic medication known as an interleukin antagonist. It treats moderate-to-severe eczema (also known as atopic dermatitis) in people ages 12 years and older. It's not a first-choice medication, but is only used when topical medications haven't worked well or aren't recommended. Adbry (tralokinumab) is injected under the skin every 2 to 4 weeks, under the guidance of a healthcare professional (HCP). If appropriate, your care team will teach you how to do self-injections at home. Some of the more common side effects of Adbry (tralokinumab) include upper respiratory tract infections.

Last reviewed on March 27, 2024
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What is Adbry (tralokinumab)?

What is Adbry (tralokinumab) used for?

  • Moderate-to-severe eczema in people who previously tried or can't use topical medications

How Adbry (tralokinumab) works

Adbry (tralokinumab) is an immune modulator known as an interleukin antagonist. It targets interleukin-13 (IL-13), a protein that's part of your immune system that can cause inflammation. Adbry (tralokinumab) stops IL-13 from working. This lowers inflammation in your skin to help treat symptoms of eczema or atopic dermatitis, such as inflammation and itchiness of the skin.

Drug Facts

Common BrandsAdbry
Drug ClassInterleukin-13 (IL-13) antagonist
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Adbry (tralokinumab)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Other Side Effects

  • High eosinophil (a type of white blood cell) count

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious allergic reactions: difficulty breathing; hives; swelling of your face, lips, tongue, or throat
  • Infection: fever; cough; difficulty breathing; diarrhea; weakness; sweating; chills; scaly, itchy, or burning skin

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Pain, redness, or irritation at injection site
pros-and-cons

Pros and cons of Adbry (tralokinumab)

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Pros

Works well to treat moderate-to-severe eczema

Given every 2 to 4 weeks

Available as prefilled syringes

Can be stored at room temperature for 2 weeks, making it convenient for traveling

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Cons

Can't be used in children younger than 12 years old

Only available as an injection under the skin

Might need to give yourself 2 separate injections per dose (and 4 injections for the loading dose)

Doesn't cure eczema

pharmacist-tips

Pharmacist tips for Adbry (tralokinumab)

pharmacist
  • Tell your healthcare professional (HCP) or pharmacist that you're taking Adbry (tralokinumab) before receiving any vaccines. This is because you shouldn't receive live vaccines, because it's not known if Adbry (tralokinumab) affects your immune system and raises your risk of infection from the vaccine.

    • Ask your dermatologist if you still need to take any other medications for eczema when you start Adbry (tralokinumab). They might ask you to also use a topical steroid or topical calcineurin inhibitor, depending on how severe your symptoms are.

      • Let your dermatologist know if you become pregnant while using Adbry (tralokinumab). Adbry (tralokinumab) hasn't been well-studied in human pregnancy, so it's unclear whether you should continue this medication. Your dermatologist can talk with you about the benefits and risks of continuing Adbry (tralokinumab), as well as about other options for treating eczema during pregnancy.

        Tips for using Adbry (tralokinumab) at home

        • Make sure you know how to give yourself the injection to avoid hurting yourself or accidentally wasting any of the medication. Carefully review the instructions for use or video. Let your dermatologist or pharmacist know if you have any questions.

          • Store Adbry (tralokinumab) prefilled syringes in the refrigerator in the original container away from light. Don't freeze them. When it's time for your dose, take Adbry (tralokinumab) out of the refrigerator and allow it to warm up to room temperature (takes about 30 minutes). Don't try to warm up the syringe any other way (e.g., microwave, run under hot water, leave in sunlight), because this could damage the medication.

            • If you're traveling and don't have access to a refrigerator, Adbry (tralokinumab) can be kept at room temperature for up to 2 weeks. Don't place the medication back into a refrigerator after it's reached room temperature.

              • Always check to make sure the medication is clear and colorless to pale yellow before using it. If it's cloudy, discolored, has many particles (solid pieces), or the syringe cap is missing, don't use it. Contact your HCP or pharmacist to see if it's possible to get a replacement.

                • Inject Adbry (tralokinumab) under your skin in either your stomach (at least 2 inches away from the belly button) or thighs. Caregivers can also help inject the medication under the skin of your upper arm. Never inject the medication into the muscle, veins, or through clothes.

                  • Each prefilled syringe contains 150 mg of Adbry (tralokinumab). This means you'll need four injections if your dose is 600 mg, or two injections if your dose is 300 mg. Inject each syringe during your dose at different sites within the same body area. For your next dose, choose different injection sites from those you used last time. Don't inject into tender, damaged, bruised, or scarred skin so you don't hurt yourself or damage the skin even more.

                    • Throw away Adbry (tralokinumab) syringes after each use, even if you see any leftover medication inside. The medication doesn't contain any preservatives to keep germs and bacteria out once you open it.

                      • After your injection, place your syringe in a sharps container or a heavy-duty plastic container (e.g., empty milk carton, laundry detergent bottle) to lower the risk of needle-stick injuries. Don't throw away syringes, needles, or On-Body Injectors into your trash can. Visit the FDA's website for guidance on how to throw it away safely your sharps container in your specific state.

                        faqs

                        Frequently asked questions about Adbry (tralokinumab)

                        Does Adbry (tralokinumab) cause weight gain?
                        People who used Adbry (tralokinumab) didn't report any changes in body weight in clinical studies. If you notice changes in your weight while using Adbry (tralokinumab), talk with your healthcare professional (HCP). They can examine you and discuss with you about possible other causes of your weight changes.
                        Is Adbry (tralokinumab) a steroid?
                        No, Adbry (tralokinumab) isn't a steroid; it's a biologic medication. Your HCP might prescribe Adbry (tralokinumab) along with corticosteroids to treat your eczema, depending on how severe your condition is.
                        Is Adbry (tralokinumab) an immunosuppressant?
                        Adbry (tralokinumab) is an immune modulator, meaning it cause changes in your immune system. This medication blocks a certain protein in your immune system called interleukin-13 (IL-13), which lowers inflammation. While Adbry (tralokinumab) can dampen your immune system, it doesn't suppress your immune system to the same degree as transplant or chemotherapy medications.
                        How long does Adbry (tralokinumab) take to work?
                        It might take about 4 months for Adbry (tralokinumab) to work. People who took Adbry (tralokinumab) in clinical studies were evaluated after 4 months of treatment. Many people saw improvements in their skin and eczema symptoms at this time. It's possible that some people might notice their skin getting better before this time. Talk to your dermatologist if you have questions about how well Adbry (tralokinumab) is working for you.
                        What's the difference between Adbry (tralokinumab) and Dupixent (dupilumab)?
                        Both Adbry (tralokinumab) and Dupixent (dupilumab) are immune modulators approved to treat moderate-to-severe eczema. They block very similar immune proteins in the immune system. Both medications are injected under the skin, typically every 2 weeks. One main difference between them is that Dupixent (dupilumab) is approved for children ages 6 months and older, whereas Adbry (tralokinumab) is approved for children ages 12 years and older. Ask your dermatologist if you have more questions about the differences between Adbry (tralokinumab) and Dupixent (dupilumab).
                        When was Adbry (tralokinumab) approved?
                        Adbry (tralokinumab) was first approved by the FDA in December 2021 for moderate-to-severe eczema in people who previously tried or can't receive topical medication.
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                        What are the risks and warnings for Adbry (tralokinumab)?

                        Adbry (tralokinumab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                        risk-warning

                        Serious allergic reactions

                        Serious allergic reactions to Adbry (tralokinumab) are possible, including life-threatening reactions like anaphylaxis (e.g., closing of the throat). If you notice a choking sensation, difficulty breathing, dizziness, sweating, nausea, or swelling around your eyes, lips, or tongue while taking Adbry (tralokinumab), get medical attention right away.

                        risk-warning

                        Eye side effects

                        Adbry (tralokinumab) can cause pink eye and eye inflammation. These eye problems eventually went away in most people. Contact your dermatologist or optometrist if you notice changes in vision, blurry vision, eye irritation, or itchy or watery eyes while taking Adbry (tralokinumab).

                        risk-warning

                        Possible risk of infections

                        It's not completely known if Adbry (tralokinumab) can weaken your immune system's response against certain infections, such as parasitic infections. Let your dermatologist know if you have an infection before starting this medication so you can get treated for it first. If you develop an infection during Adbry (tralokinumab) therapy and antiparasitic medications don't help, you might have to stop taking Adbry (tralokinumab) until your infection goes away.

                        risk-warning

                        Caution when getting vaccines

                        Avoid getting live vaccines because it's not known whether they're safe to get while you're taking Adbry (tralokinumab). Examples of live vaccines include Varivax (chickenpox vaccine) and MMR (measles, mumps, and rubella vaccine). It's best to be up to date on all your vaccines before you start Adbry (tralokinumab). Let your HCP or pharmacist know that you're taking Adbry (tralokinumab) before you get any vaccines.

                        dosage

                        Adbry (tralokinumab) dosage forms

                        Typical dosing for Adbry (tralokinumab)

                        Adbry (tralokinumab) is injected under skin into the thigh, stomach, or upper arm (if given by a caregiver).

                        • Adults: The typical dose is 600 mg injected under the skin as a single dose, then 300 mg injected every 2 weeks.

                        • Children (ages 12 years and older): The typical dose is 300 mg injected under the skin as a single dose, then 150 mg injected every 2 weeks.

                        After 4 months of treatment, your dermatologist might ask you to inject Adbry (tralokinumab) 300 mg once a month. This is only an option for people who weigh less than 220 pounds and have achieved clear or almost clear skin.

                        Your dermatologist might prescribe Adbry (tralokinumab) along with topical corticosteroids and topical calcineurin inhibitors.

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                        alternatives

                        What are alternatives to Adbry (tralokinumab)?

                        There are a number of medications that your doctor can prescribe in place of Adbry (tralokinumab). Compare a few possible alternatives below.
                        Adbry (tralokinumab)
                        Used for:
                        • Moderate-to-severe eczema in people who previously tried or can't use topical medications

                        $4011.66 Lowest GoodRx priceView Prices
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                        References

                        Best studies we found

                        American Academy of Allergy, Asthma & Immunology. (2024). Immunomodulator allergy medications.

                        Bieber, T. (2020). Interleukin-13: Targeting an underestimated cytokine in atopic dermatitis. Allergy.

                        Centers for Disease Control and Prevention. (2024). About parasites.

                        View All References (6)

                        LEO Pharma Inc. (2023). A step-by-step guide to injecting Adbry® (tralokinumab-ldrm) at home.

                        LEO Pharma Inc. (2024). Adbry- tralokinumab-ldrm injection, solution [package insert]. DailyMed.

                        LEO Pharma Inc. (n.d.). Treatment resources & videos.

                        National Eczema Society. (n.d.). Topical calcineurin inhibitors (TCIs).

                        U.S. Food and Drug Administration. (2021). Safely using sharps (needles and syringes) at home, at work and on travel.

                        U.S. Food and Drug Administration. (2023). Drug trials snapshots: Adbry.

                        GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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