Ubrelvy
Ubrelvy (ubrogepant) is a migraine medication called a calcitonin gene-related peptide (CGRP) receptor antagonist. It can treat sudden migraine attacks in adults. Ubrelvy (ubrogepant) is a tablet you take by mouth. You take one dose when you feel a migraine starting. If needed, you can take a second dose at least 2 hours later. Your dose depends if Ubrelvy (ubrogepant) interacts with the other medications you take. Side effects include nausea and tiredness.
What is Ubrelvy (ubrogepant)?
What is Ubrelvy (ubrogepant) used for?
Treatment of migraine attacks with or without aura in adults
How Ubrelvy (ubrogepant) works
Ubrelvy (ubrogepant) is a calcitonin gene-related peptide (CGRP) receptor antagonist. It blocks CGRP, a protein in the brain that plays a role in causing migraine.
By blocking CGRP, Ubrelvy (ubrogepant) helps reduce migraine pain.
Drug Facts
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What are the side effects of Ubrelvy (ubrogepant)?
Common Side Effects
- Nausea (up to 4%)
- Sleepiness (up to 3%)
- Dry mouth (up to 2%)
Serious Side Effects
- Serious allergic reaction: hives, rash, itchy skin, swelling of the lips or tongue, swelling of the throat, trouble breathing
Source: DailyMed
More on Ubrelvy (ubrogepant) side effects
The following side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
- Increase in blood pressure
- Raynaud syndrome—cool, numb, or painful fingers or toes that may change color from pale, to blue, to red
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
Pros and cons of Ubrelvy (ubrogepant)
Pros
A tablet that's taken by mouth
Helps treat sudden migraine attacks
Good option when triptans like sumatriptan (Imitrex) haven't worked well
Cons
Takes 1 to 2 hours to start working
Not for preventing migraines
Can interact with other medications, like verapamil and phenobarbital
Pharmacist tips for Ubrelvy (ubrogepant)
You can take Ubrelvy (ubrogepant) with or without food. If it's hurting your stomach, you can try taking it with food to help. Keep in mind that taking it with a high-fat meal can make the medication take longer to work.
Take Ubrelvy (ubrogepant) as soon as your migraine starts. If your migraine doesn't fully go away after 2 hours, you can take another dose that same day. Don't take more than a total of 200 mg in a day.
It's not common, but Ubrelvy (ubrogepant) can sometimes make you feel very sleepy. Don't drive or do anything that needs your full attention until you know how this medication affects you.
Don't take Ubrelvy (ubrogepant) to treat more than 8 separate migraines in a month. It's not clear how safe this is. If you have more than 8 migraines a month, let your prescriber know. They can consider other options to help with your symptoms. Or, they might suggest a medication to prevent migraines.
Let your prescriber know if you eat grapefruit or drink grapefruit juice often. They might need to lower your Ubrelvy (ubrogepant) dose to make sure it's safe. Grapefruit can raise the amount of medication in your body. This can put you at higher risk of side effects like nausea and sleepiness.
Tell your prescriber and pharmacist about all the medications you take. This also includes vitamins and supplements. Your care team can check for drug interactions that might be harmful. Your prescriber might need to change the dose of Ubrelvy (ubrogepant) to keep you safe. If needed, your prescriber might switch you to a different migraine medication.
Frequently asked questions about Ubrelvy (ubrogepant)
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What are the risks and warnings for Ubrelvy (ubrogepant)?
Ubrelvy (ubrogepant) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Allergic reactions
It's possible to have an allergic reaction to Ubrelvy (ubrogepant). This can look like a rash, hives, or itchy skin. But it can also be more serious and life-threatening. Serious reactions include swelling in the face or throat, trouble breathing, and anaphylaxis.
Allergic reactions can happen minutes, hours, or even days after taking Ubrelvy (ubrogepant). Most are mild and happen within hours. But if you have an allergic reaction, get medical help right away to be safe. This is especially important if you have trouble breathing.
High blood pressure
Risk factors: History of high blood pressure
CGRP antagonists like Ubrelvy (ubrogepant) can raise blood pressure in some people. This can happen at any time during treatment. But it's usually happened within a week of taking Ubrelvy (ubrogepant).
Tell your prescriber if you have high blood pressure. They might ask you to check your blood pressure at home. If your blood pressure stays higher than usual, let your care team know. Your prescriber can check if you need blood pressure medication or if you should try a different migraine medication.
Raynaud's phenomenon
Risk factors: History of Raynaud's phenomenon
Some people who took a CGRP antagonist like Ubrelvy (ubrogepant) developed Raynaud's phenomenon. If you already have this condition, it could get worse.
Raynaud's phenomenon causes color changes in your hands and feet. They can turn pale or more red depending on how much blood is flowing through. It can also cause pain in your fingers and toes. Sometimes, the pain can be severe enough that it needs hospital care or makes daily life harder.
Stop taking Ubrelvy (ubrogepant) and talk to your prescriber if you notice any signs of Raynaud's. They can give you tips on managing this problem. Let them know if symptoms don't go away.
Ubrelvy (ubrogepant) dosage forms
Typical dosing for Ubrelvy (ubrogepant)
The typical dose is 50 mg or 100 mg by mouth, with or without food, at the first sign of a migraine attack.
If your migraine doesn't go away, you can take a second dose at least 2 hours after your first dose. Don't take more than 200 mg per day.
Your dose might differ if you have kidney problems or liver problems. Your dose might also be different if you take certain medications that interact with Ubrelvy (ubrogepant).
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Ubrelvy (ubrogepant) contraindications
Take medications that strongly interact with Ubrelvy (ubrogepant). Examples include itraconazole (Sporanox and clarithromycin
What are alternatives to Ubrelvy (ubrogepant)?
Treatment of migraine attacks with or without aura in adults
Treatment of migraine attacks with or without aura in adults
Treatment of migraines with or without aura in adults
Prevention of migraines with or without aura in adults
What is the latest news about Ubrelvy (ubrogepant)?
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References
Best studies we foundAllergan, Inc. (2025). Ubrelvy- ubrogepant tablet [package insert]. DailyMed.
Jakate, A., et al. (2021). Effects of CYP3A4 and P-glycoprotein inhibition or induction on the pharmacokinetics of ubrogepant in healthy adults: Two phase 1, open-label, fixed-sequence, single-center, crossover trials. International Headache Society.
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