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Symbicort

budesonide / formoterol
Used for Asthma, COPD

Symbicort (budesonide / formoterol) is a combination inhaler used to treat asthma and chronic obstructive pulmonary disease (COPD). It contains two medications: budesonide, a steroid, and formoterol, a long-acting beta-agonist (LABA). Both medications work together to reduce inflammation in the lungs and open up your airways. The typical dose is two puffs by mouth twice a day, usually about 12 hours apart. Common side effects include common cold symptoms, headache, and sore throat.

Reviewed by:Last reviewed on July 22, 2025
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What is Symbicort (budesonide / formoterol)?

Featuring Nabila Ismail, PharmDReviewed by Daisy Chau, PharmD | July 31, 2024

What is Symbicort (budesonide / formoterol) used for?

How Symbicort (budesonide / formoterol) works

Symbicort (budesonide / formoterol) is a combination of two medications.

  • Budesonide is a corticosteroid. It works by lowering swelling and irritation in your lungs. This helps make breathing easier.

  • Formoterol is a long-acting beta-agonist (LABA). It relaxes the muscles in your airways. This opens up the lungs, helping air flow more easily.

When does Symbicort (budesonide / formoterol) start working?Time passed since treatment started:
MINUTES
Initial effect
HOURS
DAYS
WEEKS
Full effect
MONTHS

Drug facts

Common BrandsSymbicort
Drug ClassInhaled corticosteroid / LABA
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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Side effects of Symbicort (budesonide / formoterol)

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Asthma:

  • Common cold symptoms (10-11%)
  • Upper respiratory tract infection (8-11%)
  • Headache (7-11%)
  • Sore throat (6-9%)
  • Sinus infection (5-6%)

COPD:

  • Common cold symptoms (7%)
  • Oral thrush (6%)
  • Bronchitis (5%)

Less Common Side Effects

Asthma:

  • Flu symptoms
  • Back pain
  • Nasal congestion
  • Stomach discomfort
  • Vomiting
  • Oral thrush

COPD:

  • Sinus infection
  • Upper respiratory tract infection

Symbicort (budesonide / formoterol) serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Sudden narrowing of the airways: worsening trouble breathing, coughing, wheezing
  • Severe allergic reaction: rash, hives, swelling of the face or tongue, breathing problems
  • Overdose: chest pain, a fast or irregular heartbeat, tremor, headache, nervousness
  • Pneumonia: more mucus, fever, more coughing, mucus that changes color, chills, more trouble breathing
  • Other infections: fever, body aches, tiredness, vomiting, pain, chills, nausea
When do Symbicort (budesonide / formoterol) possible side effects begin and end?
Time passed since treatment started:
M
H
D
W
M
Throat pain
Risk of common cold
Risk of thrush
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following Symbicort (budesonide / formoterol) side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Flu-like symptoms—fever, chills, muscle pain, cough, headache, fatigue
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
  • Increase in blood pressure
  • Low adrenal gland function—nausea, vomiting, loss of appetite, unusual weakness or fatigue, dizziness
  • Muscle pain or cramps
  • Pain, tingling, or numbness in the hands or feet
  • Sinus pain or pressure around the face or forehead
  • Thrush—white patches in the mouth
  • Wheezing or trouble breathing that is worse after use

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

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Pros and cons of Symbicort (budesonide / formoterol)

Pros

  • Long-term treatment for both COPD and asthma
  • Might feel relief in as soon as 15 minutes for asthma
  • Safe for children 6 years and older for asthma
  • Combines two medications into one inhaler for convenience

Cons

  • Won't work well for asthma attacks or COPD flare ups
  • Can cause thrush in mouth or throat as a side effect
  • Taken 2 times a day
  • Possible bone loss if used for a long time
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Pharmacist tips for Symbicort (budesonide / formoterol)

pharmacist
  • Take Symbicort (budesonide / formoterol) every day, 2 puffs in the morning and 2 puffs in the evening. Try to take the doses about 12 hours apart to keep the medication working all day.
  • If you miss a dose of Symbicort (budesonide / formoterol), just take your next dose at your usual time. Don’t take extra puffs to make up for the missed dose.
  • Symbicort (budesonide / formoterol) isn't used to treat symptoms of an asthma attack or a COPD flare up. or sudden asthma attacks or COPD flare-ups. If you have wheezing, coughing, shortness of breath, or chest tightness, tell your prescriber right away. Always keep a rescue inhaler like albuterol with you for emergencies.
  • Get your routine tests done on time while you're taking Symbicort (budesonide / formoterol). These checkups help your prescriber see if the medication is working and not causing problems. Tests might include blood work, breathing tests, and eye exams.
  • Talk to your prescriber or pharmacist before starting any new medications. Some medications can interact with Symbicort (budesonide / formoterol) and cause more side effects.

How to use Symbicort (budesonide / formoterol):

  • Write use-by date: Once you open the foil pouch, write down the use-by date on the inhaler (3 months from the day you opened it). Throw away the inhaler when it hits 3 months or shows “0” doses, whichever comes first.
  • Priming the inhaler: If you're using a new inhaler, haven't used it in over a week, or if you drop it, you'll need to "prime" it. This means shaking it and then spraying 2 puffs into the air. Priming makes sure you get the right dose when you use it.
  • Taking a dose: Shake the inhaler, breathe out fully, and place the mouthpiece in your mouth. Inhale deeply while spraying 1 puff, then hold your breath for up to 10 seconds. Repeat for the second puff.
  • After use: Rinse your mouth with water and spit it out. This helps prevent a yeast infection called oral thrush). Call your prescriber if you notice white patches in your mouth or throat.
  • Cleaning: Wipe the mouthpiece with a dry cloth once a week so the medication doesn't build up and block the spray through the mouthpiece. Don't rinse the inhaler with water.
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Risks and warnings for Symbicort (budesonide / formoterol)

Symbicort (budesonide / formoterol) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Worsening asthma or COPD

  • Risk factors: Using albuterol more often | Using too much Symbicort (budesonide / formoterol)

Symbicort (budesonide / formoterol) shouldn't be used for asthma attacks or serious breathing problems from asthma or COPD. If you suddenly have trouble breathing or start wheezing, use a rescue inhaler like albuterol instead.

If you notice you're using your rescue inhaler more often, tell your prescriber right away. This could mean your condition is getting worse and your treatment might need to change. Don't take more than 2 puffs in the morning and 2 puffs in the evening.

Overdose

  • Risk factors: Using too much Symbicort (budesonide / formoterol) | Using together with other LABAs

Using Symbicort (budesonide / formoterol) more often, at a higher dose than prescribed, or with other LABAs can raise your risk of overdose. Taking too much can lead to serious side effects like heart problems, and in rare cases, even death. Get medical help right away if you have symptoms like chest pain, a fast or irregular heartbeat, tremor, headache, or nervousness.

Oral thrush

  • Risk factor: Not rinsing and spitting after using Symbicort (budesonide / formoterol)

Symbicort (budesonide / formoterol) can sometimes cause a yeast infection in your mouth or throat called oral thrush. Symptoms include white patches inside of your mouth, redness, soreness, or pain while eating or swallowing. If you notice these symptoms, tell your prescriber right away since you might need an antifungal medication to treat it. To help prevent this, rinse your mouth with water after each use and spit it out — don’t swallow the water.

Pneumonia

  • Risk factors: COPD

Symbicort (budesonide / formoterol) can raise your risk of certain lung infections like pneumonia, especially if you have COPD. Keep in mind that pneumonia can look a lot like a COPD flare up, so tell your prescriber if you have more mucus, a fever, more coughing, mucus that changes color, chills, or more trouble breathing. They can help figure out the cause and choose the right treatment for you.

Higher risk of infection

  • Risk factors: Active, chronic (long-term), or recurrent infection | Medical conditions that weaken the immune system | Taking other medications that can weaken the immune system

Symbicort (budesonide / formoterol) can make it harder for your body to fight infections. Infections like tuberculosis, chickenpox, and measles can be more serious if you're using this medication. Don't use Symbicort (budesonide / formoterol) if you have an active or ongoing infection without talking with your prescriber first. Let them know right away if you have signs of an infection, such as a fever, body aches, tiredness, vomiting, pain, chills, or nausea.

Changes in stress hormone levels

  • Risk factors: High doses of Symbicort (budesonide / formoterol) | Using Symbicort (budesonide / formoterol) for a long time | Stressful events (e.g., surgery)

Rarely, using an inhaled steroid like Symbicort (budesonide / formoterol) for a long time can lead to adrenal insufficiency, a condition where your body doesn't make enough of its own steroid hormones. To help prevent this, your prescriber will recommend the lowest dose of Symbicort (budesonide / formoterol) that works for you, for the shortest amount of time. If you need to use the medication long term, your prescriber might order some lab tests to check how well your adrenal glands are working. Let your prescriber know if you feel very tired, weak, or sick to your stomach — especially after surgery or during times of stress — as these could be signs of low steroid levels.

Sudden narrowing of the airways

Although rare, Symbicort (budesonide / formoterol) can cause paradoxical bronchospasm, which means your breathing suddenly gets worse right after using the inhaler. This can be life-threatening if not treated quickly. If you notice more wheezing, shortness of breath, or coughing after using Symbicort (budesonide / formoterol), stop using it and use a rescue inhaler (like albuterol) right away. Contact your prescriber since you might need to switch to a different treatment.

Serious allergic reaction

Some people might have an allergic reaction immediately after using Symbicort (budesonide / formoterol). This could include hives, swelling of the face or throat, rash, or trouble breathing. If you notice any of these signs, stop using the inhaler and get medical help right away.

Heart and nervous system problems

  • Risk factors: History of heart problems | Using too much Symbicort (budesonide / formoterol)

Using too much Symbicort (budesonide / formoterol) can lead to serious issues like seizures, heart problems, and changes in blood pressure. To stay safe, only use it exactly as your prescriber tells you. Talk to your prescriber right away if you experience chest pain, fast heart rate, headache, tremor, nausea, dizziness, and trouble sleeping.

Risk of bone loss

  • Risk factors: Using Symbicort (budesonide / formoterol) long term | Older adult | Unable to move for a long period of time | Family history of osteoporosis | Poor diet | Postmenopausal | Smoking | Using medications that can cause bone loss

People taking Symbicort (budesonide / formoterol) for a long time might be at risk for bone loss. It's not clear if this leads to broken bones, but the risk is higher if you're an older adult, postmenopausal, have a poor diet, smoke, or take certain medications. Your prescriber might check your bone density regularly to make sure your bones stay healthy. If you've had broken bones or have a history of osteoporosis, talk to your prescriber before starting this medication.

Poor growth

  • Risk factors: Children

Inhaled corticosteroids like Symbicort (budesonide / formoterol) can slow down growth in children. If your child is using this medication, their height should be checked regularly to make sure they're growing normally. To lower the risk of side effects, your child's prescriber will try to use the lowest dose of Symbicort (budesonide / formoterol) that still works well to control symptoms.

Eye problems

  • Risk factors: Long-term use of Symbicort (budesonide / formoterol) | History of eye problems like glaucoma or cataracts | Higher dose of Symbicort (budesonide / formoterol)

Using Symbicort (budesonide / formoterol) for a long time can raise eye pressure, worsen glaucoma, or lead to cataracts. Talk to your prescriber right away if you experience blurry vision, eye discomfort, or other changes in your vision. You might need an eye exam to check for these problems.

Low potassium and high blood sugar

Symbicort (budesonide / formoterol) can sometimes cause low potassium levels, which can affect your heart rhythm. This is usually temporary and doesn’t need treatment. Let your care team know if you have muscle pain or weakness, muscle cramps, or abnormal heartbeat as these can be signs of low potassium.

In rare cases, Symbicort (budesonide / formoterol) can also raise blood sugar levels. Let your prescriber know if you're feeling more thirsty or hungry than usual, confused, or urinating more often. These can be signs of high blood sugar.

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Symbicort (budesonide / formoterol) dosage

The average cost for 1 inhaler of 120 doses of 160mcg/4.5mcg of Symbicort (budesonide / formoterol) is $92.01 with a free GoodRx coupon. This is 46.25% off the average retail price of $171.19.
inhalerInhaler
DosageQuantityPrice as low asPrice per unit
120 doses of 80mcg/4.5mcg1 inhaler$77.80$77.80
120 doses of 160mcg/4.5mcg1 inhaler$92.01$92.01

Typical dosage for Symbicort (budesonide / formoterol)

Symbicort (budesonide / formoterol) comes in two different strengths:

  • Symbicort 80/4.5 - each puff has 80 mcg of budesonide and 4.5 mcg of formoterol
  • Symbicort 160/4.5 - each puff has 160 mcg of budesonide and 4.5 mcg of formoterol.

Asthma

  • Adults and children 12 years and older: The typical dose is two puffs of Symbicort 80/4.5 OR Symbicort 160/4.5 by mouth twice a day, 12 hours apart.
  • Children 6 to 11 years old: The typical dose is two puffs of Symbicort 80/4.5 by mouth twice a day, 12 hours apart.

COPD

  • Adults: The typical dose is two puffs of Symbicort 160/4.5 by mouth twice a day, 12 hours apart.
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How much does Symbicort (budesonide / formoterol) cost?

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Symbicort (budesonide / formoterol) contraindications

Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Symbicort (budesonide / formoterol) will not be safe for you to take.

  • Asthma attacks
  • Severe episodes of asthma or COPD
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What are alternatives to Symbicort (budesonide / formoterol)?

There are a number of medications that your doctor can prescribe in place of Symbicort (budesonide / formoterol). Compare a few possible alternatives below.
Symbicort (budesonide / formoterol)
Used for:
$77.80Lowest GoodRx priceView prices
Used for:
  • Maintenance treatment of asthma
  • Maintenance treatment of COPD - Advair Diskus 250/50 only
$55.41Lowest GoodRx priceView prices
Used for:
  • Maintenance treatment of asthma in people ages 5 years and older
$199.00Lowest GoodRx priceView prices
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News about Symbicort (budesonide / formoterol)

References

Best studies we found

AstraZeneca Pharmaceuticals LP. (2019). SYMBICORT- budesonide and formoterol fumarate dihydrate aerosol [package insert]. DailyMed.

Magee, J. S., et al. (2018). Paradoxical bronchoconstriction with short-acting beta agonist. American Journal of Case Reports.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.