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Acetaminophen/Dextromethorphan/Doxylamine Coupon - Acetaminophen/Dextromethorphan/Doxylamine 325mg/15mg/6.25mg capsule

acetaminophen / dextromethorphan / doxylamine

Generic Nyquil
Used for Allergic Rhinitis, Cough, Fever, Insomnia, Pain

Nyquil Cold and Flu is a combination medication containing acetaminophen (a pain reliever), dextromethorphan (a cough suppressant), and doxylamine (an antihistamine). It's used to treat cold and flu symptoms, like sore throat, fever, cough, runny nose, sneezing, and aches, in adults and children. Nyquil Cold and Flu is available as pills and a liquid. This medication can make you feel sleepy and dizzy as side effects.

Reviewed by:Last reviewed on January 8, 2024
basics-icon

What is Nyquil Cold and Flu?

What is Nyquil Cold and Flu used for?

Temporarily relieves common cold and flu symptoms, including:

  • Cough
  • Sore throat
  • Headache
  • Minor aches and pains
  • Fever
  • Runny nose
  • Sneezing

How Nyquil Cold and Flu works

Nyquil Cold and Flu is a combination of three medications:

When does Nyquil Cold and Flu start working?Time passed since treatment started:
MINUTES
Initial effect
HOURS
Full effect
DAYS
WEEKS
MONTHS

Drug facts

Common BrandsVicks Nyquil Cold and Flu
Drug ClassAnalgesic / Cough suppressant / Antihistamine
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityOver-the-counter
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Side effects of Nyquil Cold and Flu

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Less Common Side Effects

Nyquil Cold and Flu serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Allergic reactions: rash; hives; difficulty breathing; swelling of face, lips, tongue, or throat
  • Serious skin reaction: skin reddening, blisters, rash
  • Liver damage: severe stomach pain, yellowing of skin or whites of the eyes, nausea, vomiting, loss of appetite
  • Excessive sleepiness or dizziness
  • Serotonin syndrome: fast heart rate, sweating, muscle stiffness or spasms, high fever, confusion
When do Nyquil Cold and Flu possible side effects begin and end?
Time passed since treatment started:
M
H
D
W
M
Sleepiness
Dizziness

Source: DailyMed

The following Nyquil Cold and Flu side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth
  • Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
  • Trouble passing urine

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

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Pros and cons of Nyquil Cold and Flu

Pros

  • Available over the counter
  • Works within 30 minutes to relieve cold and flu symptoms
  • Available in capsules and a liquid
  • Combines three medications in one product for convenience
  • Available as a lower-cost generic

Cons

  • Needs to be taken multiple times per day
  • Can cause extreme sleepiness
  • More difficult to customize the dose since it's a fixed combination of three medications
  • Need to avoid alcohol while taking it
  • Not meant for long-term use
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Pharmacist tips for Nyquil Cold and Flu

pharmacist
  • You can take Nyquil Cold and Flu with or without food. If it upsets your stomach, try taking the medication with food.
  • Nyquil Cold and Flu is only meant to be used short-term. You should stop using this medication and talk to your provider if your pain or cough lasts longer than a week or stops and returns, or fever that worsens or lasts for more than 3 days. These can be signs of a more serious condition that Nyquil Cold and Flu won't be able to treat.
  • Nyquil Cold and Flu can make you sleepy or dizzy during the day, which can affect your ability to focus, think, or react. Don't drive until you know how the medication affects you. To prevent daytime sleepiness, it might help to take the least amount of medication possible (that will still relieve your symptoms) at night.
  • While Nyquil Cold and Flu usually makes adults sleepy, it's possible for children who use this medication to become overly excited or energetic. If this happens to your child, speak to your child's provider. They can recommend other treatment options.
  • Tell your provider or pharmacist about all the medications you're taking so they can check for interactions. For example, the acetaminophen in Nyquil Cold and Flu can interact with warfarin (Coumadin) and raise your risk for bleeding. Also, the doxylamine in Nyquil Cold and Flu can interact with sleep or anxiety medications and make you more sleepy.
  • Don't start any new medications while taking Nyquil Cold and Flu, especially other medications containing acetaminophen, other cough suppressants, or other antihistamines, without talking to your provider or pharmacist first. Doing so can raise your risk of overdose and severe side effects.
  • Don't take Nyquil Cold and Flu with a monoamine oxidase inhibitor (MAOI), such as selegiline or phenelzine (Nardil). This combination can raise your risk for severe side effects (e.g., serotonin syndrome, dizziness). If you're currently taking or have taken an MAOI in the last 2 weeks, don't use Nyquil Cold and Flu. Contact your provider for other options to treat your cold or flu symptoms.

More tips for Nyquil Cold and Flu liquid form:

  • The liquid products might contain 10% of alcohol. But there are alcohol-free alternatives available, such as Vicks Nyquil Alcohol Free or Coricidin-Maximum Strength Multi-Symptom Flu.
  • Some liquid products contain sodium. Ask your provider if it's okay to use a product with sodium if you have a history of heart problems and you're on a low-salt diet.
  • Use a medication dose cup or an oral syringe to measure your dose of Nyquil Cold and Flu. Don't use household spoons because they aren't always accurate and might cause you to take the wrong dose.
  • Store at room temperature in the original bottle it came from and protect it from light.
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Risks and warnings for Nyquil Cold and Flu

Nyquil Cold and Flu can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Liver damage

  • Risk factors: Drinking three or more alcoholic beverages a day | Taking other medications containing acetaminophen | Taking too much Nyquil Cold and Flu | History of liver disease

Warning IconTaking too much acetaminophen can cause permanent and life-threatening liver damage. For adults, the maximum amount of acetaminophen that can be taken is 3 or 4 grams in a 24-hour period, depending on your provider's instructions. For children, ask your child's provider.

blank warning iconSpeak to your provider before using Nyquil Cold and Flu if you have liver problems, since it can cause further damage to your liver. Avoid drinking alcohol while taking this medication.

blank warning iconSigns of liver problems include dark urine, fatigue, stomach pain, or yellowing of skin or eyes. If you notice any of these symptoms, call your provider right away.

Serotonin syndrome

  • Risk factors: Taking monoamine oxidase inhibitors (MAOI) 14 days before starting Nyquil Cold and Flu | Taking other medications that raise serotonin levels in your brain

Serotonin syndrome is a rare, but potentially life-threatening condition where there's too much serotonin in the brain. Serotonin is one of the chemicals in your brain responsible for your mood. Your risk for this condition goes up if you use Nyquil Cold and Flu with other medications that affect serotonin levels, such as antidepressants (e.g., sertraline (Zoloft), duloxetine (Cymbalta)), MAOIs (e.g., phenelzine (Nardil)), lithium, and certain migraine medications (e.g., sumatriptan (Imitrex)). Make sure your provider knows about all the medications you take (including over-the-counter medications and supplements) before starting Nyquil Cold and Flu so they can check that your medications are safe for you. Symptoms of serotonin syndrome include fast heart rate, sweating, muscle stiffness or spasms, high fever, and confusion. Get medical help right away if you have any of these symptoms.

Accidental overdose

Nyquil Cold and Flu contains an analgesic (acetaminophen), a cough suppressant (dextromethorphan), and an antihistamine (doxylamine), which can be found in many other over-the-counter products. Using more than one medication containing acetaminophen, dextromethorphan, doxylamine, can lead to an accidental overdose and cause serious side effects. These serious side effects include liver failure, seizures, hallucinations (seeing things that aren't real), or even death. To prevent an accidental overdose, read package labels carefully. If you're not sure if a product has any similar ingredients, ask your pharmacist. If you or your loved one experiences an accidental overdose, get medical help as soon as possible or contact a poison control center at 1-800-222-1222.

Worsening of medical conditions

  • Risk factors: Liver disease | Glaucoma | Cough from asthma or another breathing problem | Mucus-producing cough | Breathing problems (e.g., emphysema, long-term bronchitis) | Enlarged prostate gland

Don't take Nyquil Cold and Flu if you have any of the risk factors listed above unless your provider said it's safe to do so. Taking this medication can worsen your condition(s) and cause serious side effects. Make sure your provider knows about all medical conditions you have or have had in the past before starting Nyquil Cold and Flu.

Allergic skin reactions

Although rare, Nyquil Cold and Flu can cause serious skin reactions, such as rash, blisters, skin reddening, or skin peeling. If you notice changes in your skin, stop using Nyquil Cold and Flu and get medical attention right away.

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Nyquil Cold and Flu dosage

The average cost for 16 capsules of 325mg/15mg/6.25mg of Nyquil Cold and Flu is $9.54 with a free GoodRx coupon.
bottle of liquidBottle of liquid
DosageQuantityPrice as low asPrice per unit
355ml of 650mg/30mg/12.5mg/30ml1 bottle$11.74$11.74
capsuleCapsule
DosageQuantityPrice as low asPrice per unit
325mg/15mg/6.25mg16 capsules$9.54$0.60

Typical dosage for Nyquil Cold and Flu

Nyquil Cold and Flu and its generics might come in different strengths and have different dosing directions. Read the manufacturer's label for instructions specific for your medication. Some examples include:

Nyquil Cold and Flu liquid: Each 30 mL dose cup contains 650 mg of acetaminophen, 30 mg of dextromethorphan, and 12.5 mg of doxylamine.

  • Adults and children 12 years and older: The typical dose is 30 mL (2 tablespoons) by mouth every 6 hours. Don't take more than 120 mL (8 tablespoons) in a 24-hour period unless your provider specifically told you to do so.
  • Children 4 to 11 years old: Ask your child's provider.
  • Children 3 years and younger: Don't use.

Nyquil Cold and Flu capsules: Each capsule contains 325 mg of acetaminophen, 15 mg of dextromethorphan, and 6.25 mg of doxylamine.

  • Adults and children 12 years and older: The typical dose is 2 capsules by mouth with water every 6 hours. Don't take more than 8 capsules in a 24-hour period unless your provider specifically told you to do so.
  • Children 4 to 11 years old: Ask your child's provider.
  • Children 3 years and younger: Don't use.
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How much does Nyquil Cold and Flu cost?

To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Nyquil Cold and Flu (generic)
GoodRx lowest price

$8.38

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Nyquil Cold and Flu contraindications

Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Nyquil Cold and Flu will not be safe for you to take.

  • Taking Nyquil Cold and Flu with any other medication containing acetaminophen
  • Currently take or have taken an MAOI in the last 2 weeks
  • Using to make a child sleep
alternatives-icon

What are alternatives to Nyquil Cold and Flu?

There are a number of medications that your doctor can prescribe in place of Nyquil Cold and Flu. Compare a few possible alternatives below.
Nyquil Cold and Flu
Used for:

Temporarily relieves common cold and flu symptoms, including:

  • Cough
  • Sore throat
  • Headache
  • Minor aches and pains
  • Fever
  • Runny nose
  • Sneezing
$8.38Lowest GoodRx priceView prices
Used for:

Short-term relief of symptoms from the common cold or flu:

  • Cough
  • Runny nose
  • Sneezing
  • Sore throat
  • Headache
  • Minor aches and pains
  • Fever
$5.11Lowest GoodRx priceView prices
Used for:

Short-term relief of symptoms from the common cold and flu:

  • Minor aches and pains
  • Headache
  • Cough
  • Sore throat
  • Runny nose
  • Sneezing
  • Itchy nose or throat
  • Itchy, watery eyes due to hay fever or allergies
  • Fever
$18.01Lowest GoodRx priceView prices
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News about Nyquil Cold and Flu

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Nyquil Cold and Flu images

Green P30 - Quality Choice NightTime Cold & Flu Multi-Symptom Relief 325mg-15mg-6.25mg Softgel
This medicine is Green Capsule Imprinted With "P30".Green P30 - Quality Choice NightTime Cold & Flu Multi-Symptom Relief 325mg-15mg-6.25mg Softgel

References

Best studies we found

Borowy, C. S., et al. (2023). Antihistamine toxicity. StatPearls.

Church, M. K., et al. (2013). Pharmacology of antihistamines. Indian Journal of Dermatology.

Oh, S., et al. (2023). Dextromethorphan. StatPearls.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.