
minocycline ER
Minocycline extended-release (ER) is a tetracycline antibiotic used to treat acne in adults and children 12 years and older. As an ER tablet, it slowly releases medication into your body over time. It's typically taken by mouth once a day, with or without food. Common side effects include tiredness, dizziness, and itching.
What is Minocycline ER?
What is Minocycline ER used for?
- Moderate-to-severe acne
How Minocycline ER works
Minocycline ER is a tetracycline antibiotic. It works by lowering the amount of the P. acnes bacteria that naturally live on your skin. This helps reduce inflammation and can improve acne.
Drug facts
| Common Brands | Solodyn |
|---|---|
| Drug Class | Tetracycline antibiotic |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | Lower-cost generic available |
| Availability | Prescription only |
Side effects of Minocycline ER
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Tiredness (9%)
- Dizziness (9%)
- Itching (5%)
Less Common Side Effects
- Feeling unwell
- Sleepiness
- Hives
- Ringing in the ears
- Joint pain
- Spinning sensation
Minocycline ER serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Infectious diarrhea: watery diarrhea (often several times a day), bloody stools, stomach cramps and pain, fever, loss of appetite
- High pressure around the brain: headache, dizziness, blurred vision, vision changes, blind spots
- Severe allergic reaction: shortness of breath, hives, chest tightness, facial or throat swelling
- Severe skin reactions: rash, blisters, red skin, fever, swollen lymph nodes
More on Minocycline ER side effects
The following Minocycline ER side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Increased pressure around the brain—severe headache, blurry vision, change in vision, nausea, vomiting
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Rash, fever, and swollen lymph nodes
- Redness, blistering, peeling, or loosening of the skin, including inside the mouth
- Severe or prolonged diarrhea
- Unusual vaginal discharge, itching, or odor
- Unusual weakness or fatigue, fever, headache, skin rash, muscle or joint pain, loss of appetite, pain, tingling, or numbness in the hands or feet
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Change in skin color
- Change in tooth color
- Diarrhea
- Dizziness
- Heartburn
- Skin reactions on sun-exposed areas
- Upset stomach
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Pros and cons of Minocycline ER
Pros
- Only taken once a day
- Can take with or without food
- Approved for children as young as 12 years old
Cons
- Can make your skin more sensitive to sunlight
- Interacts with blood thinners and birth control pills
- Not safe in pregnancy or breastfeeding
Pharmacist tips for Minocycline ER
- You can take minocycline ER with or without food. But taking it with food and drinking plenty of water can help prevent throat irritation. You might also want to stay sitting or standing for a while after taking it.
- Swallow the minocycline ER tablet whole without crushing or cutting it.
- When you first start minocycline ER, you might feel dizzy or lightheaded. Be careful driving or doing tasks that require focus until you know how it affects you.
- Diarrhea can happen while taking minocycline ER. In rare cases, you might have watery and bloody stools, even up to 2 months after stopping it. Call your prescriber right away if this happens.
- Minocycline ER can make your skin more sensitive to the sun. Protect your skin and wear sunscreen with SPF 30 or higher when outdoors.
- Take minocycline ER at least 3 hours before or after antacids or supplements that contain magnesium, aluminum, iron, or calcium. These products can make the medication work less well.
- Minocycline ER can interact with blood thinners like warfarin. Tell your prescriber if you take a blood thinner so they can monitor you closely.
- Tell your care team if you develop a rash while taking minocycline ER. A rash can be a sign of a serious reaction.
- Don't take minocycline ER during pregnancy because it can cause permanent tooth discoloration and slow bone growth in an unborn baby. If you become pregnant while taking this medication, stop it and contact your prescriber right away.
- Don't breastfeed while taking minocycline ER and for 4 days after your last dose. Talk to your prescriber about safe feeding options for your baby during this time.
Risks and warnings for Minocycline ER
Minocycline ER can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Harm to unborn babies
Minocycline ER can harm an unborn baby, including causing problems with bone growth and permanent tooth discoloration. You shouldn't take this medication if you're pregnant or trying to become pregnant.
Minocycline ER can also make some birth control pills work less well. Use a backup birth control method while taking this medication. If you become pregnant during treatment, stop taking it and contact your prescriber right away.
Tooth discoloration
- Risk factors: Children 8 years and younger | Pregnancy | Long-term use or repeated use of minocycline ER
Tetracycline antibiotics like minocycline ER can affect teeth while they are still developing in young children. The teeth can turn a permanent yellow, gray, or brown color. In rare cases, the enamel might not form correctly, which can make the teeth weaker.
These tooth changes can also happen to an unborn baby if taken during pregnancy, especially in the second half. Tooth side effects are more common with long-term use, but they can also happen after several short courses.
Slow bone growth
- Risk factors: Children 8 years and younger | Pregnancy
Tetracycline antibiotics like minocycline ER can slow bone growth when used during the second and third trimesters of pregnancy or in children younger than 8 years old. This happens because the medication binds to calcium in growing bones.
Infectious diarrhea
- Risk factors: Use of multiple antibiotics | Long-term use of antibiotics | Older age | Recent hospital stay | People with weakened immune systems | Previous infection from or known exposure to C. diff
Antibiotics, including minocycline ER, can cause a serious infection called Clostridium difficile-associated diarrhea (CDAD). This happens when antibiotics change the normal bacteria in your gut, allowing harmful C. diff bacteria to grow too much. Call your care team right away if you have watery diarrhea, fever, stomach pain or cramps, nausea, vomiting, or loss of appetite. Tell your prescriber if you develop diarrhea during treatment or even up to 2 months after stopping the antibiotic.
Severe allergic and serious skin reactions
In rare cases, minocycline ER can cause serious and life-threatening allergic and skin reactions, including Stevens-Johnson syndrome and drug reaction with eosinophilia and systemic symptom (DRESS). Stop taking it and get medical help right away if you have trouble breathing, facial swelling, fever, rash, peeling skin, or swollen lymph nodes.
Kidney and liver damage
- Risk factors: History of kidney or liver problems
In rare cases, minocycline ER can harm your kidneys, especially if you already have kidney problems. It can also cause liver damage, which can lead to liver failure. Contact your prescriber right away if you notice dark urine, changes in how much you urinate, stomach pain, or yellowing of your skin or the whites of your eyes.
Brain and nerve effects
Minocycline ER can cause you to feel lightheaded, dizzy, or like the room is spinning (vertigo). If this happens, don't drive or use heavy machinery until you know how this medication affects you. These symptoms might improve while you're taking it and usually go away after you stop the medication.
High pressure in the brain
- Risk factors: Women of childbearing age who are overweight | History of high pressure in the brain | Also taking isotretinoin
Tetracycline antibiotics, including minocycline ER, have been linked to a rare condition called intracranial hypertension. This is when pressure builds up around your brain. Symptoms can include headache, blurry vision, double vision, or vision loss. Women of childbearing age who are overweight or who have had this condition before have a higher risk. Taking isotretinoin with minocycline can raise this risk and should be avoided.
This condition usually improves after stopping the medication, but permanent vision loss is possible. Tell your prescriber right away if you notice vision changes. You might need an eye exam, and your care team will monitor you for several weeks after stopping the medication.
Autoimmune problems
- Risk factors: Taking minocycline ER long-term
Taking tetracycline antibiotics like minocycline ER might be linked to rare autoimmune problems, especially with long-term use. Symptoms can include fever, rash, joint pain, and feeling very tired. If you notice these symptoms after taking the medication for a while, stop it and check in with your prescriber.
Sun sensitivity
Some people taking minocycline ER can become sensitive to the sun. This means your skin may burn more easily in the sun and you might get a stronger sunburn than usual. To protect yourself, limit direct sunlight, avoid tanning beds, wear protective clothing like a wide-brimmed hat, and use sunscreen with SPF 30 or higher when outdoors.
Darkening of body tissues
Minocycline ER can cause your skin and nails to become darker. This can happen even if you haven't been taking it for very long. It can also affect other areas, such as your eyes, inside your mouth, or even some internal organs.
These color changes are usually not harmful. But if you notice them, contact your prescriber to make sure they aren't a sign of another condition.
New infection
- Risk factors: Taking minocycline ER long-term
Taking minocycline ER for a long time can sometimes lead to a new infection caused by bacteria or fungi that this medication can't treat. Don't take minocycline ER longer than your prescriber recommends. Tell your prescriber if you notice signs of a new infection or if your original symptoms don't improve.
Minocycline ER dosage
| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 45mg | 30 tablets | $69.74 | $2.32 |
| 90mg | 30 tablets | $69.74 | $2.32 |
| 135mg | 30 tablets | $69.74 | $2.32 |
| 65mg | 30 tablets | $141.67 | $4.72 |
| 115mg | 30 tablets | $162.06 | $5.40 |
| 80mg | 30 tablets | $80.33 | $2.68 |
| 105mg | 30 tablets | $64.28 | $2.14 |
| 55mg | 30 tablets | $60.43 | $2.01 |
Typical dosage for Minocycline ER
The dose is based on your weight.
The typical dose is 1 mg/kg by mouth once a day for 12 weeks.
- 45 to 49 kg: 45 mg per day
- 50 to 59 kg: 55 mg per day
- 60 to 71 kg: 65 mg per day
- 72 to 84 kg: 80 mg per day
- 85 to 96 kg: 90 mg per day
- 97 to 110 kg: 105 mg per day
- 111 to 125 kg: 115 mg per day
- 126 to 136 kg: 135 mg per day
Your dose might differ if you have kidney problems.
How much does Minocycline ER cost?
Minocycline ER contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Minocycline ER will not be safe for you to take.
- Allergy to tetracycline antibiotics
What are alternatives to Minocycline ER?
Doxycycline hyclate is used to prevent malaria due to the parasite Plasmodium falciparum and to treat many different infections caused by bacteria. Some examples include:
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