Lotrel, Hyzaar, and More: 12 Combination Blood Pressure Medications (Plus Ways to Save)
Combination blood pressure medications, such as Lotrel and Ziac, can help you simplify your routine by reducing the number of pills you take every day.
benazepril / HCTZ
Used for Hypertension
Used for Hypertension
Lotensin HCT is a combination blood pressure medication for adults. It contains benazepril (an angiotensin-converting enzyme (ACE) inhibitor) and hydrochlorothiazide (a thiazide diuretic). It's available as a brand name and lower-cost generic tablet that's taken by mouth once per day. The dosage will generally depend on how high your blood pressure is and if you're taking, or have recently taken, other blood pressure medications. Some common side effects of Lotensin HCT (benazepril / hydrochlorothiazide) include dizziness, tiredness, and headache.
What is Lotensin HCT (benazepril / hydrochlorothiazide)?
What is Lotensin HCT (benazepril / hydrochlorothiazide) used for?
- High blood pressure in adults
How Lotensin HCT (benazepril / hydrochlorothiazide) works
Lotensin HCT is a combination of two medications that work together to lower blood pressure:
- Benazepril is an angiotensin-converting enzyme (ACE) inhibitor. It relaxes your blood vessels by blocking a protein (ACE) that normally squeezes your blood vessels.
- Hydrochlorothiazide is a thiazide diuretic, which is a water pill. It works in your kidneys to remove extra water and salt. This helps lower blood pressure.
Drug facts
| Common Brands | Lotensin HCT |
|---|---|
| Drug Class | ACE inhibitor / Diuretic (water pill) combo |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | Lower-cost generic available |
| Availability | Prescription only |
Side effects of Lotensin HCT (benazepril / hydrochlorothiazide)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Dizziness (6%)
- Tiredness (5%)
- Dizziness when suddenly standing up (4%)
- Headache (3%)
- Cough (2%)
Less Common Side Effects
- Nausea
- Difficulty getting or maintaining an erection
- Sleepiness
- "Spinning" sensation
Lotensin HCT (benazepril / hydrochlorothiazide) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Angioedema (severe swelling): swelling of the face, arms or legs, lips, tongue, or throat
- Severe allergic reaction: swelling of your lips, tongue, throat, or face, trouble breathing, rash
- Dangerously low blood pressure: dizziness, lightheadedness, pale skin, feeling faint
- Serious kidney problems: urinating less often than usual, swelling in your feet, ankles, or hands, unexplained weight gain
- Liver problems: yellowing of the skin or eyes, stomach pain, nausea, vomiting, confusion
The following Lotensin HCT (benazepril / hydrochlorothiazide) side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Less common
Blurred vision
confusion
decreased urination
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
fast, slow, or irregular heartbeat
muscle cramps or pain
numbness, tingling, pain, or weakness in the hands or feet
rapid breathing
seizures
sunken eyes
sweating
thirst
trembling
unusual tiredness or weakness
weakness and heaviness of the legs
wrinkled skin
Rare
Black, tarry stools
burning, crawling, itching, numbness, prickling, "pins and needles" , or tingling feelings
chills
cough or hoarseness
darkened urine
dizziness or lightheadedness
feeling of constant movement of self or surroundings
headache
indigestion
loss of appetite
lower back or side pain
painful or difficult urination
pains in the stomach or side, possibly radiating to the back
persistent non-healing sore
pink growth
reddish patch or irritated area
sensation of spinning
shiny bump
sores, ulcers, or white spots on the lips or in the mouth
swollen glands
trouble breathing
unusual bleeding or bruising
vomiting
white, yellow or waxy scar-like area
yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
decreased interest in sexual intercourse
excessive muscle tone
feeling of constant movement of self or surroundings
inability to have or keep an erection
loss in sexual ability, desire, drive, or performance
muscle stiffness
muscle tension or tightness
sensation of spinning
sleepiness or unusual drowsiness
Rare
Blistering, peeling, loosening of the skin
hives or welts, itching, skin rash
increased sensitivity of skin to sunlight
joint or muscle pain
pinpoint red or purple spots on the skin
redness of the skin
redness or other discoloration of the skin
red irritated eyes
red skin lesions, often with a purple center
severe sunburn
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Get your GoodRx coupon
$67.37
GoodRx discount
$23.91
Pros and cons of Lotensin HCT (benazepril / hydrochlorothiazide)
Pros
- Contains two first-choice medications for lowering blood pressure within a single pill
- Taken by mouth once per day at any time of day
- Available as a lower-cost generic
Cons
- Might take 2 to 3 weeks before maximum benefit
- Only available as a tablet
- Not safe to take during pregnancy or breastfeeding
Pharmacist tips for Lotensin HCT (benazepril / hydrochlorothiazide)
- Mark your calendar with your appointments to see your prescriber and to get any blood work done when you take Lotensin HCT (benazepril / hydrochlorothiazide). Your care team will order tests (e.g., electrolytes, kidney function, blood pressure) during treatment and might change your dose based on your results.
- You can take Lotensin HCT (benazepril / hydrochlorothiazide) with or without food at any time of day. If it hurts your stomach, taking it with food might help.
- You might want to check your blood pressure at home, keep a record of your readings, and bring this log to your medical appointments. This helps your prescriber better understand how well Lotensin HCT (benazepril / hydrochlorothiazide) is working for you and they can recommend any dose changes if needed.
- Lotensin HCT (benazepril / hydrochlorothiazide) can cause dizziness or headaches, especially when you first start taking it or when your healthcare team raises the dose. These symptoms should lessen as you continue taking the medication. Stand up slowly from sitting or lying positions to prevent falls. Let your prescriber know if you feel faint, lightheaded, or confused.
- Dry cough is a well-known side effect of ACE-inhibitors, like benazepril. It's possible for you to get a cough from taking Lotensin HCT (benazepril / hydrochlorothiazide). This side effect can appear at any time during treatment. If you get a cough from Lotensin HCT (benazepril / hydrochlorothiazide) and it's bothersome, talk to your prescriber. They might switch you to a different blood pressure medication.
- Take Lotensin HCT (benazepril / hydrochlorothiazide) exactly as prescribed. Don't change your dose or stop taking the medication suddenly without talking to your prescriber first. Doing so can cause your blood pressure to rise quickly. You might need to lower your dose slowly over time before you can completely stop taking it.
- It's best to avoid or limit how much alcohol you drink because it can cause a drop in your blood pressure. This can lead to dizziness and falls.
- Make sure to maintain a balanced diet, including a low-salt diet, while taking Lotensin HCT (benazepril / hydrochlorothiazide) to help lower your blood pressure. Depending on your risk factors and other medical problems, it's possible you might be able to stop taking Lotensin HCT (benazepril / hydrochlorothiazide) if your blood pressure gets within goal.
- Both benazepril and hydrochlorothiazide can interact with many other medications, such as lithium (Lithobid) and non-steroidal anti-inflammatory drugs (NSAIDs) (e.g., ibuprofen (Advil, Motrin)). Make sure to tell your care team about all the medications you're taking before and during treatment with Lotensin HCT (benazepril / hydrochlorothiazide).
- If you're pregnant, thinking of getting pregnant, or breastfeeding and are taking Lotensin HCT (benazepril / hydrochlorothiazide), contact your prescriber right away. Your prescriber will likely recommend a different medication that's safe during pregnancy or breastfeeding.
Risks and warnings for Lotensin HCT (benazepril / hydrochlorothiazide)
Lotensin HCT (benazepril / hydrochlorothiazide) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Not for use during pregnancy
Benazepril in Lotensin HCT can cause severe and sometimes life-threatening harm to unborn babies, so it shouldn't be taken during pregnancy. If you find out that you're pregnant while taking Lotensin HCT (benazepril / hydrochlorothiazide), stop and let your prescriber know right away. If you're pregnant before starting Lotensin HCT (benazepril / hydrochlorothiazide) or thinking of becoming pregnant during treatment, discuss with your healthcare professional (HCP) about safer options to treat your blood pressure.
Angioedema (swelling)
- Risk factors: Black people | Having angioedema in the past
People who take medications that contain an ACE inhibitor, like benazepril in Lotensin HCT, can experience a rare, but serious side effect called angioedema. This involves swelling in different parts of the body, including the face, throat, and tongue. Swelling of the tongue or throat area can be potentially life-threatening, since it can make it difficult to breathe. Angioedema can happen at any time during treatment. This risk is higher in Black people than in non-Black people. Get medical attention immediately if you experience swelling in any of the areas mentioned above, stomach pain, or difficulty breathing. You'll have to stop taking Lotensin HCT (benazepril / hydrochlorothiazide) if this happens.
Low blood pressure
- Risk factors: Not enough fluid in your body | Having diarrhea or vomiting for a long time | Low salt levels in your body | Taking higher doses of diuretic medications
Sometimes, taking Lotensin HCT (benazepril / hydrochlorothiazide) can cause your blood pressure to drop too much. This can cause you to feel dizzy, tired, or lightheaded. This side effect is more common when you first start Lotensin HCT (benazepril / hydrochlorothiazide) or when the dose is raised. Make sure to stay well-hydrated. If your blood pressure drops too much and you feel dizzy, make sure to sit down slowly while holding onto something and let your care team know. If you fall and hit your head, get medical help right away. If you feel dizzy, lightheaded, faint, tired, or confused while taking Lotensin HCT (benazepril / hydrochlorothiazide), contact your prescriber.
Kidney damage
- Risk factors: Severe heart failure | Kidney problems | Not enough fluid in your body | Taking other medications that can cause kidney damage | History of narrow heart valves (aortic stenosis)
Sometimes, Lotensin HCT (benazepril / hydrochlorothiazide) can affect your kidneys and cause them to not work as well. The risk is higher for people who have certain types of kidney problems, such as renal artery stenosis or very severe heart failure. Your prescriber might order lab tests every so often to make sure your kidneys are healthy and working properly. If you develop kidney problems, or if your kidney problems worsen while taking Lotensin HCT (benazepril / hydrochlorothiazide), your prescriber might recommend that you stop taking this medication. Let your prescriber know if you're urinating less often than usual, as this could be a sign that your kidneys aren't working as well.
Liver failure
Rarely, people who took ACE inhibitors like benazepril in Lotensin HCT (benazepril / hydrochlorothiazide) have developed a blocked bile duct. This condition can lead to liver problems or liver failure. Your prescriber might order blood tests to check your liver health from time to time. If you notice symptoms of liver problems, such as tiredness, stomach pain, or yellowing of your skin, let your care team know right away.
Changes in electrolyte, blood sugar, and cholesterol levels
Lotensin HCT (benazepril / hydrochlorothiazide) can affect the level of certain electrolytes in your body, including sodium, potassium, and magnesium. Your prescriber might order blood work regularly while you're taking this medication to make sure your electrolyte levels are in a safe range. Let your care team know if you experience a fast heart beat, weakness, low energy, muscle pain or cramps, less urination than usual, nausea, or vomiting. These can be signs of electrolyte changes in your body.
In addition, Lotensin HCT (benazepril / hydrochlorothiazide) might affect your blood sugar levels and cholesterol levels. Your prescriber might also check your blood sugar and cholesterol levels regularly while you're taking this medication.
Vision problems
- Risk factors: Sulfa or penicillin allergies
Though rare, some people experience vision changes within hours or weeks after starting Lotensin HCT (benazepril / hydrochlorothiazide) because of the hydrochlorothiazide part of the medication. Tell your prescriber right away about any vision changes or eye pain and stop taking Lotensin HCT (benazepril / hydrochlorothiazide) as soon as possible. In some cases, surgery might be required to avoid permanent vision loss.
Lupus
In some rare cases, Lotensin HCT (benazepril / hydrochlorothiazide) can cause worsening of or new lupus. Let your prescriber know if you notice a rash across your cheeks and nose or feel very tired.
Lotensin HCT (benazepril / hydrochlorothiazide) dosage
The average cost for 90 tablets of 20mg/12.5mg of Lotensin HCT (benazepril / hydrochlorothiazide) is $33.50 with a free GoodRx coupon. This is 74.23% off the average retail price of $130.01. 
Tablet
Tablet| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 10mg/12.5mg | 90 tablets | $36.15 | $0.40 |
| 20mg/12.5mg | 90 tablets | $33.50 | $0.37 |
| 5mg/6.25mg | 30 tablets | $23.91 | $0.80 |
| 20mg/25mg | 90 tablets | $36.03 | $0.40 |
Typical dosage for Lotensin HCT (benazepril / hydrochlorothiazide)
Your prescriber will pick a starting dose based on things like how high your blood pressure is, which other blood pressure medications you're currently taking or have recently taken, and your risk for side effects.
- Adults: The typical starting dose is 10 mg/12.5 mg (benazepril / hydrochlorothiazide) by mouth once daily. If needed, your prescriber will raise your dose every 2 to 3 weeks. The maximum dose is 20 mg/25 mg (benazepril/hydrochlorothiazide) daily.
More on Lotensin HCT (benazepril / hydrochlorothiazide) dosage
Interactions between Lotensin HCT (benazepril / hydrochlorothiazide) and other drugs
Lotensin HCT (benazepril / hydrochlorothiazide) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Lotensin HCT (benazepril / hydrochlorothiazide). Please note that only the generic name of each medication is listed below.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Aliskiren
- Dofetilide
- Sacubitril
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Aceclofenac
- Acemetacin
- Acetyldigoxin
- Alteplase, Recombinant
- Amiloride
- Amphetamine
- Amtolmetin Guacil
- Arsenic Trioxide
- Aspirin
- Azathioprine
- Azilsartan
- Azilsartan Medoxomil
- Benzphetamine
- Bromfenac
- Bufexamac
- Candesartan Cilexetil
- Canrenoate
- Celecoxib
- Choline Salicylate
- Clonixin
- Deslanoside
- Desmopressin
- Dexibuprofen
- Dexketoprofen
- Dextroamphetamine
- Diclofenac
- Diflunisal
- Digitalis
- Digitoxin
- Digoxin
- Dipyrone
- Droperidol
- Droxicam
- Eplerenone
- Eprosartan
- Etodolac
- Etofenamate
- Etoricoxib
- Everolimus
- Felbinac
- Fenoprofen
- Fepradinol
- Feprazone
- Flecainide
- Floctafenine
- Flufenamic Acid
- Flurbiprofen
- Ibuprofen
- Indomethacin
- Irbesartan
- Ketanserin
- Ketoprofen
- Ketorolac
- Levomethadyl
- Lisdexamfetamine
- Lithium
- Lornoxicam
- Losartan
- Loxoprofen
- Lumiracoxib
- Meclofenamate
- Mefenamic Acid
- Meloxicam
- Mercaptopurine
- Methamphetamine
- Methotrexate
- Metildigoxin
- Morniflumate
- Nabumetone
- Naproxen
- Nepafenac
- Niflumic Acid
- Nimesulide
- Nimesulide Beta Cyclodextrin
- Olmesartan Medoxomil
- Ouabain
- Oxaprozin
- Oxyphenbutazone
- Parecoxib
- Phenylbutazone
- Piketoprofen
- Piroxicam
- Porfimer
- Potassium
- Proglumetacin
- Propyphenazone
- Proquazone
- Proscillaridin
- Rofecoxib
- Salicylic Acid
- Salsalate
- Sirolimus
- Sodium Salicylate
- Sotalol
- Spironolactone
- Sulindac
- Telmisartan
- Tenoxicam
- Tiaprofenic Acid
- Tolfenamic Acid
- Tolmetin
- Triamterene
- Trimethoprim
- Valdecoxib
- Valsartan
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Aminolevulinic Acid
- Azosemide
- Bepridil
- Bromfenac
- Bufexamac
- Bumetanide
- Bupivacaine
- Bupivacaine Liposome
- Capsaicin
- Carbamazepine
- Celecoxib
- Cholestyramine
- Choline Salicylate
- Clonixin
- Dexibuprofen
- Dexketoprofen
- Diclofenac
- Diflunisal
- Dipyrone
- Droxicam
- Ethacrynic Acid
- Etodolac
- Etofenamate
- Etoricoxib
- Felbinac
- Fenoprofen
- Fepradinol
- Feprazone
- Floctafenine
- Flufenamic Acid
- Flurbiprofen
- Furosemide
- Ginkgo
- Gold Sodium Thiomalate
- Gossypol
- Ibuprofen
- Indomethacin
- Ketoprofen
- Ketorolac
- Licorice
- Lornoxicam
- Loxoprofen
- Lumiracoxib
- Meclofenamate
- Mefenamic Acid
- Meloxicam
- Morniflumate
- Nabumetone
- Naproxen
- Nepafenac
- Nesiritide
- Niflumic Acid
- Nimesulide
- Nimesulide Beta Cyclodextrin
- Oxaprozin
- Oxyphenbutazone
- Parecoxib
- Phenylbutazone
- Piketoprofen
- Piretanide
- Piroxicam
- Proglumetacin
- Propionic Acid
- Propyphenazone
- Proquazone
- Rofecoxib
- Salicylic Acid
- Salsalate
- Sodium Salicylate
- Sulindac
- Tenoxicam
- Tiaprofenic Acid
- Tolfenamic Acid
- Tolmetin
- Topiramate
- Torsemide
- Valdecoxib
How much does Lotensin HCT (benazepril / hydrochlorothiazide) cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Lotensin HCT (benazepril / hydrochlorothiazide) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Lotensin HCT (benazepril / hydrochlorothiazide) will not be safe for you to take.
- Taking at the same time as aliskiren (Tekturna) in people with diabetes (high blood sugar)
- Taking at the same time or within 36 hours of neprilysin inhibitors, such as Entresto (sacubitril / valsartan)
- Not producing urine
- Allergy to sulfa medications
- Allergy to ACE inhibitors
- History of angioedema (severe swelling)
What are alternatives to Lotensin HCT (benazepril / hydrochlorothiazide)?
There are a number of medications that your doctor can prescribe in place of Lotensin HCT (benazepril / hydrochlorothiazide). Compare a few possible alternatives below.
News about Lotensin HCT (benazepril / hydrochlorothiazide)
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