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Humira

adalimumab
Used for Psoriasis, Plaque Psoriasis, Ulcerative Colitis, Rheumatoid Arthritis, Psoriatic Arthritis, Crohn's Disease, Uveitis, Ankylosing Spondylitis, Hidradenitis Suppurativa, Juvenile Idiopathic Arthritis
Used for Psoriasis, Plaque Psoriasis, Ulcerative Colitis, Rheumatoid Arthritis, Psoriatic Arthritis, Crohn's Disease, Uveitis, Ankylosing Spondylitis, Hidradenitis Suppurativa, Juvenile Idiopathic Arthritis

Humira (adalimumab) is an injection used to treat many different autoimmune conditions like rheumatoid arthritis, Crohn's disease, ulcerative colitis, and plaque psoriasis. As a TNF blocker, the medication works by blocking a protein that causes inflammation in your body. It's given as a shot under the skin once every 1 to 2 weeks, depending on your condition. Humira (adalimumab) doesn't have a true generic, but there are several similar versions called biosimilars. Common side effects include infections, injection site reactions, and headache.

Reviewed by:
reviewer
Kristianne Hannemann, PharmD
reviewer
Daisy Chau, PharmD
Last reviewed on August 5, 2025
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostAlternativesLatest newsImagesReferencesPricesMedicare
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What is Humira (adalimumab)?

What is Humira (adalimumab) used for?

How Humira (adalimumab) works

Humira (adalimumab) is a tumor necrosis factor (TNF) blocker. It works by blocking TNF, a protein in your body that plays a role in inflammation. By blocking this protein, the medication helps lower swelling and prevent damage from certain autoimmune conditions.

Drug Facts

Common BrandsHumira
Drug ClassTNF blocker
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

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What are the side effects of Humira (adalimumab)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Injection-site reaction (20%)
  • Upper respiratory tract infection (17%)
  • Headache (12%)
  • Rash (12%)
  • Sinus inflammation (11%)
  • Accidental injury (10%)
  • Nausea (9%)
  • Urinary tract infection (UTI) or bladder infection (8%)
Note: The side effects listed above were reported by adults with rheumatoid arthritis and are similar to those seen in people using Humira (adalimumab) for other conditions.

Other Side Effects

  • High cholesterol
  • High blood pressure
  • Back pain
  • Stomach pain
  • Hair loss
  • Blood in the urine
  • Flu-like symptoms

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious infection: fever, cough, weight loss, cough, loss of body fat and muscle
  • Severe allergic reaction: trouble breathing, swelling of your face or throat, hives
  • Nervous system problems: numbness and tingling, vision problems, weakness in arms or legs, dizziness
  • Blood problems: fever that doesn't go away, easy bruising or bleeding, pale skin
  • Heart failure: shortness of breath, sudden weight gain, swelling of your ankles or feet
  • Lupus-like syndrome: chest discomfort or pain, shortness of breath, joint pain, rash on your cheeks or arms that gets worse with sunlight
  • Liver problems: feeling tired, poor appetite, vomiting, yellowing of your eyes or skin, pain on the right side of your stomach

Source: DailyMed

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The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Body aches or pain

cough

ear congestion

gas with stomach pain

hoarseness

lightheadedness

loss of voice

lower back or side pain

muscle aches and pains

pain or tenderness around the eyes or cheekbones

rapid and sometimes shallow breathing

shivering

stomach fullness

stuffy nose

sunken eyes

thirst

trouble sleeping

warmth on the skin

wrinkled skin

Less common

Abnormal vaginal bleeding or discharge

agitation

arm, back, or jaw pain

black, tarry stools

bleeding from the gums or nose

blindness

bloating or swelling of the face, arms, hands, lower legs, or feet

blood in the stool or change in bowel habits

bloody or cloudy urine

blurred vision

broken bones

change in size, shape, or color of an existing mole

change in skin color

chest pain, tightness, or heaviness

chills

clear or bloody discharge from the nipple

cold hands and feet

confusion

constipation

cough

coughing or spitting up blood

decreased urination

decreased vision

depression

difficulty with breathing

difficulty, burning, or painful urination

dimpling of the breast skin

dizziness

drowsiness

eye pain

fainting

fast, slow, or irregular heartbeat

fever

forgetfulness

frequent urge to urinate

general feeling of illness

hair loss

headache

hives, itching, skin rash

increased thirst

inverted nipple

irregular breathing

irregular pulse

irritability

light colored stools

loss of appetite

lump in the breast or under your arm

lump or swelling in the stomach

mole that leaks fluid or bleeds

muscle cramps or spasms

nausea

new mole

night sweats

no blood pressure or pulse

noisy breathing

numbness or tingling in your arms, legs, or face

pain, redness, or swelling in the arms or legs without any injury present

pale skin

persistent non-healing sore on your skin

pink growth

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

raised, firm, or bright red patch

redness or swelling of the breast

seeing or hearing things that are not there

seizures

sharp back pain just below your ribs

shiny bump on your skin

slurred speech or problems with swallowing

sneezing

sore on the skin of the breast that does not heal

sore throat

sores, ulcers, or white spots on the lips or mouth

spitting up blood

stiff neck

stomach pain

stopping of the heart

sudden high fever or low grade fever for months

sweating

swelling of the face, fingers, feet, or lower legs

swollen glands

swollen neck veins

tiredness

trouble breathing

trouble thinking

unconsciousness

unexplained bruising or bleeding

unpleasant breath odor

unusual tiredness or weakness

unusual weight gain or loss

visual disturbances

vomiting

vomiting of blood or material that looks like coffee grounds

yellow skin or eyes

Incidence not known

Blistering, peeling, or loosening of the skin

diarrhea

inability to move the arms and legs

joint or muscle pain

pinpoint red spots on the skin

red skin lesions, often with a purple center

red, irritated eyes

red, scaling, or crusted skin

sudden numbness and weakness in the arms and legs

unusual bleeding or bruising

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bladder pain

bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

pounding in the ears

Less common

Abnormal healing

decrease in height

difficulty with moving

difficulty with walking

dry mouth

heartburn

indigestion

loss of hearing

loss of strength or energy

menstrual changes

muscle or joint stiffness, tightness, or rigidity

muscle pain or weakness

pain in the back, ribs, arms, or legs

shakiness in the legs, arms, hands, and feet

swelling or redness in the joints

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Humira (adalimumab)

thumbs-up

Pros

Can be used for many autoimmune conditions

Available as a ready-to-use pen that makes it easier to self-inject at home

Can be used in young children (as young as 2 years old for some conditions)

Only needs to be injected a couple times a month

Can be left at room temperature for up to 14 days if needed

thumbs-down

Cons

Raises the risk of serious infections

Can take a few weeks or longer to work

Might be difficult to inject for some people

Can't receive any live vaccines while taking the medication

Might contain rubber or latex, which can cause a reaction for those with an allergy

pharmacist-tips

Pharmacist tips for Humira (adalimumab)

pharmacist

  • Make sure you get injection training before using Humira (adalimumab). If you haven’t been trained, call your clinic or 1-800-4HUMIRA. Don’t try to give yourself the injection until you know how to do it safely.

    • If you miss a dose of Humira (adalimumab), take it as soon as you remember. Then go back to your regular schedule. If you're unsure what to do, ask your prescriber or pharmacist.

      • Humira (adalimumab) can make it harder for your body to fight infections. Call your care team if you get signs of infection, like fever, cough, or feeling tired.

        • Some people might have a serious allergic reaction to Humira (adalimumab). Get medical help right away if you have symptoms like swelling, trouble breathing, or a rash. If you're allergic to latex, know that some pen or syringe caps might contain natural rubber latex.

          • Store Humira (adalimumab) in the refrigerator in its original container to protect it from light. If you're traveling, it can stay at room temperature for up to 14 days. After that, throw it away even if you didn’t use it.

            How to inject Humira (adalimumab):

            • Take Humira (adalimumab) out of the fridge and let it sit for 15 to 30 minutes before injecting. This helps make the shot less painful. Don’t heat it up in the microwave or put it in hot water.

              • Clean your injection site on your thighs or stomach (at least 2 inches from your belly button) with an alcohol swab. Don’t inject into red, sore, or bruised skin—and use a different spot each time and use different injection sites each time.

                • After using Humira (adalimumab), throw away the used pen, needle, or syringe in a sharps container. You can buy one or use a heavy-duty plastic container, like an empty laundry detergent bottle. Follow your local rules for how to safely throw it out when it’s full.

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                  faqs

                  Frequently asked questions about Humira (adalimumab)

                  Humira works by targeting and blocking a protein in the body called tumor necrosis factor (TNF). In …  Learn more
                  Humira works by intentionally lowering your immune response. At the same time, your immune system al…  Learn more
                  Humira (adalimumab) is a biologic medication used for many autoimmune disorders, including rheumatoi…  Learn more
                  The most common Humira side effect is injection site reactions. Respiratory infections, headaches, a…  Learn more
                  Several medications have potential long-term risks, including Humira. For instance, it's been rarely…  Learn more
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                  What are the risks and warnings for Humira (adalimumab)?

                  Humira (adalimumab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                  risk-warning

                  Serious infections

                  • Risk factors: Taking other medications that weaken the immune system, including Orencia (abatacept) and Kineret (anakinra) | Older adults | Active, chronic, or recurrent infection | Traveling to high risk areas | Having other conditions that raise the risk of infection

                    Humira (adalimumab) can raise your risk of serious or life-threatening infections. This is more common in older adults, people with other health problems, and those taking medications that weaken the immune system — like methotrexate, Orencia (abatacept), Kineret (anakinra), or corticosteroids.

                    Let your prescriber know about your past medical history before starting Humira (adalimumab), especially if you've ever had tuberculosis or hepatitis B. They’ll check your risk for infections before beginning treatment.

                    While you’re taking Humira (adalimumab), it’s important to watch for any signs of infection, such as fever, chills, cough, shortness of breath, or feeling very tired. If you develop any of these, contact your prescriber right away. They might pause your treatment and start medication to help treat the infection.

                    risk-warning

                    Cancers

                    • Risk factors: Taking other medications that weaken the immune system | History of cancer | People with chronic obstructive pulmonary disease (COPD) with a history of smoking

                      In clinical trials, more people developed cancer while taking Humira (adalimumab) compared to those who didn’t take it. The most common types reported were lymphoma, leukemia, and skin cancers. Your prescriber will review your risk before you start treatment and continue to monitor you while you're taking the medication. Talk to your healthcare team if you have any questions or concerns.

                      risk-warning

                      Severe allergic reactions

                      Serious allergic reactions like anaphylaxis and swelling of the face or throat have been reported in people taking Humira (adalimumab). If you notice a rash, itching, trouble breathing, or swelling in your face or throat, stop taking the medication and get medical help right away.

                      risk-warning

                      Nervous system effects

                      • Risk factors: Currently have or recently developed a nervous system condition

                        Although rare, Humira (adalimumab) has been linked to nervous system problems, including conditions like multiple sclerosis (MS) and Guillain-Barré syndrome. These problems affect the brain, spinal cord, or nerves and might cause symptoms like vision changes, weakness, or numbness. If you already have a nervous system problem, or recently developed one, your prescriber will be cautious when deciding if Humira (adalimumab) is right for you. If new symptoms develop, you might need to stop taking the medication.

                        risk-warning

                        Low blood cell counts

                        It's rare, but some people have had low blood cell counts while taking Humira (adalimumab). This can make it harder for your body to fight infections and raise your risk of bleeding. Call your prescriber if you get a fever that doesn’t go away, bruise or bleed easily, or notice that your skin looks pale.

                        risk-warning

                        Heart failure

                        People taking Humira (adalimumab) have had new or worsening cases of heart failure. If you already have heart failure, talk to your prescriber — they’ll weigh the risks and benefits before starting treatment. Let your care team know right away if you experience symptoms like swelling in your legs, shortness of breath, or sudden weight gain.

                        risk-warning

                        Lupus-like syndrome

                        In rare cases, treatment with Humira (adalimumab) can lead to a condition called lupus-like syndrome. Tell your prescriber right away if you have chest pain that doesn’t go away, shortness of breath, joint pain, or a rash on your cheeks or arms that gets worse in sunlight. If you have lupus-like syndrome, you might have to stop taking the medication.

                        risk-warning

                        Live vaccines

                        It's typically okay to get some vaccines while you're taking Humira (adalimumab), but you should avoid live vaccines. These might not be safe or work as well while you're receiving treatment with this medication. Children should be up to date on all their vaccines before starting Humira (adalimumab). Talk to your prescriber or pharmacist to make sure it’s safe to get any vaccines while you're taking this medication.

                        dosage

                        Humira (adalimumab) dosage forms

                        Typical dosing for Humira (adalimumab)

                        Adults

                        • Rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: The typical dose is 40 mg injected under the skin every other week.

                        • Crohn's disease and ulcerative colitis: The typical dose is 160 mg injected under the skin on Day 1, then 80 mg on Day 15. Starting Day 29, the maintenance dose is 40 mg every other week.

                        • Plaque psoriasis and uveitis: The typical dose is 80 mg injected under the skin on Day 1, then 40 mg every other week starting 1 week after the first dose.

                        • Hidradenitis suppurativa: The typical dose is 160 mg injected under the skin on Day 1, then 80 mg on Day 15. Starting Day 29, the maintenance dose is 40 mg every week OR 80 mg every other week.

                        Children

                        • Juvenile idiopathic arthritis and uveitis:

                          • Weight 22 lbs to less than 33 lbs: The typical dose is 10 mg injected under the skin every other week.

                          • Weight 33 lbs to less than 66 lbs: The typical dose is 20 mg injected under the skin every other week.

                          • Weight 66 lbs and more: The typical dose is 40 mg injected under the skin every other week.

                        • Crohn's disease:

                          • Weight 37 lbs to less than 88 lbs: The typical dose is 80 mg injected under the skin on Day 1, then 40 mg on Day 15. Starting Day 29, the maintenance dose is 20 mg every other week.

                          • 88 lbs and more: The typical dose is 160 mg injected under the skin on Day 1, then 80 mg on Day 15. Starting Day 29, the maintenance dose is 40 mg every other week.

                        • Ulcerative colitis:

                          • Weight 44 lbs to less than 88 lbs: The typical dose is 80 mg injected under the skin on Day 1, followed by 40 mg on Day 8, and then 40 mg on Day 15. Starting Day 29, the maintenance dose is 40 mg every other week OR 20 mg every week.

                          • Weight 88 lbs and more: The typical dose is 160 mg injected under the skin on Day 1, followed by 80 mg on Day 8, and then 80 mg on Day 15. Starting Day 29, the maintenance dose is 80 mg every other week OR 40 mg every week.

                        • Hidradenitis suppurativa:

                          • Weight 66 lbs to less than 132 lbs: The typical dose is 80 mg injected under the skin on Day 1. Starting on Day 8, the maintenance dose is 40 mg every other week.

                          • Weight 132 lbs and more: The typical dose is 160 mg injected under the skin on Day 1, then 80 mg on Day 15. Starting Day 29, the maintenance dose is 40 mg every week or 80 mg every other week.

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                        interactions

                        Interactions between Humira (adalimumab) and other drugs

                        Humira (adalimumab) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Humira (adalimumab). Please note that only the generic name of each medication is listed below.

                        More on Humira (adalimumab) interactions

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                        Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                        What are alternatives to Humira (adalimumab)?

                        There are a number of medications that your doctor can prescribe in place of Humira (adalimumab). Compare a few possible alternatives below.
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                        Humira (adalimumab) images

                        yellow - Adalimumab 40mg / 0.4mL Pre-Filled Pen Solution for Injection
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                        References

                        Best studies we found

                        AbbVie Inc. (2025). Humira- adalimumab kit; Humira- adalimumab injection, solution [package insert]. DailyMed.

                        National Health Service. (2022). Common questions about adalimumab.

                        Solhjoo, M., et al. (2023). Drug-induced lupus erythematosus. StatPearls.

                        GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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