Key takeaways
Sertraline (Zoloft) and Adderall (dextroamphetamine / amphetamine salts) are both medications used to treat mental health conditions, but they belong to different drug classes and have different uses. Sertraline is a selective serotonin reuptake inhibitor (SSRI) primarily used for depression and anxiety disorders, while Adderall is a stimulant used for attention deficit-hyperactivity disorder (ADHD) and narcolepsy. Sertraline is taken once daily, available in tablet and liquid forms, and is available as a generic. Adderall comes as an immediate-release tablet or an extended-release capsule and is usually taken once or twice daily. Common side effects of sertraline include nausea and diarrhea, whereas Adderall can cause trouble sleeping and loss of appetite. Sertraline can interact with alcohol and other medications that increase serotonin levels, while Adderall has a risk of misuse and can affect your blood pressure. Both medications require careful monitoring by your healthcare team to manage side effects and interactions.
