Key takeaways
Ondansetron (Zofran) and prochlorperazine (Compro) are both medications used to treat nausea and vomiting, but they have some key differences. Ondansetron (Zofran) is an antiemetic that works by blocking serotonin in the brain and is available in various forms, including tablets, orally disintegrating tablets, liquid, and injections. It is often used after surgery or cancer treatments and can be taken by both adults and children. On the other hand, prochlorperazine (Compro) is a phenothiazine that blocks dopamine and is only available as a rectal suppository. It is typically used for severe nausea and vomiting and is not recommended for children. Prochlorperazine (Compro) can cause serious side effects like extreme sleepiness and uncontrolled muscle movements, making it less favorable as a first-choice treatment. While both medications are available as generics, ondansetron (Zofran) offers more flexibility in administration and is generally considered safer, especially for long-term use.
