Key takeaways
Testosterone enanthate, available as Xyosted and as an intramuscular injection, is used for testosterone replacement therapy to treat low testosterone levels in males. Both medications belong to the same drug class and are controlled substances (Schedule III) due to their potential for misuse and dependency. However, they differ in their administration routes and FDA-approved uses. Xyosted is a brand-name version of testosterone enanthate that comes as a prefilled autoinjector. It's FDA-approved to treat low testosterone levels in adult males as a once-weekly injection under the skin. Testosterone enanthate is also available in generic form as an injection into the muscle (IM). The IM form is approved for delayed puberty in males and metastatic breast cancer in females as well as low testosterone levels in adult males. It's injected into the buttock muscle once every 2 to 4 weeks. Common side effects of Xyosted include high blood pressure and injection site bruising, while the intramuscular form can cause acne and pain at the injection site.
