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Compare Methyltestosterone vs. Testopel

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Methyltestosterone (Methitest) and Testopel (testosterone pellets) are both used to treat low testosterone and delayed puberty in males, but they have some key differences. Methyltestosterone can also be used to treat breast cancer in females. Methyltestosterone is taken orally in pill form, while Testopel is implanted under the skin as pellets. Methyltestosterone is available in a generic form, making it less expensive, whereas Testopel is only available as a brand medication and might be more costly. Testopel pellets are long-acting and need to be implanted every 3 to 6 months, which requires a minor surgical procedure lasting about 15 minutes. On the other hand, methyltestosterone is easier to take but can cause serious liver damage with long-term use. Both medications can cause side effects like enlargement of male breasts and acne, but Testopel also carries risks of infection at the implantation site and the pellets coming out of the skin. Neither medication is recommended for men with breast or prostate cancer nor women who are pregnant or may become pregnant.

  • Methyltestosterone (Methitest)
    Testopel (testosterone pellets)
  • Methyltestosterone (Methitest)
    Testopel (testosterone pellets)

  • Summary of Methyltestosterone vs. Testopel

    Summary for Testosterone replacement
    Prescription only

    Methyltestosterone (Methitest) is a pill form of testosterone used for testosterone replacement therapy (TRT) in males with low testosterone levels. It's also used to treat females with breast cancer that has spread to other parts of the body. The medication comes as a tablet or capsule and is typically taken by mouth once a day. Your dosage will depend on your condition and how you respond to treatment. Possible side effects include nausea, acne, and headaches.

    Summary for Testosterone replacement
    Prescription only

    Testopel (testosterone pellets) is an implantable pellet medication used as long-acting testosterone replacement therapy. It treats certain males with low testosterone and delayed puberty. The pellets are implanted, or placed under your skin, by a healthcare professional (HCP) typically every 3 to 6 months. Side effects include pain and swelling at the implantation site, as well as sexual side effects like more frequent erections and changes in sex drive.

  • Indications of Methyltestosterone vs. Testopel

    Indications for

    Males

    •Low testosterone (hypogonadism)
    •Delayed puberty

    Females

    •Breast cancer that has spread to other parts of the body
    Indications for
    •Low testosterone (hypogonadism)
    •Delayed puberty

  • Pros and Cons of Methyltestosterone vs. Testopel

    Pros and Const for Testosterone replacement
    Pros
    •Is a pill taken by mouth
    •Restores healthy testosterone levels in men
    •Supports male development during puberty
    Cons
    •Risk of liver problems with long-term use
    •Potential for serious heart problems and blood clots
    •Risk of misuse and dependence since it's a controlled substance
    Pros and Const for Testosterone replacement
    Pros
    •A long-acting testosterone replacement medication
    •Implanted every 3 to 6 months
    •Can be used in children and adults
    •Unlike testosterone gel, there’s no risk of accidentally exposing others to testosterone
    Cons
    •Can cause pain and swelling at the implantation site
    •Risk of infections or extrusions at the implantation site
    •Is a surgical procedure that must be done at the prescriber's office
    •Dose adjustments are difficult since they require surgical removal or addition of pellets

  • Common Side Effects of Methyltestosterone vs. Testopel

    Common Side Effects for

    Males

    •Breast enlargement
    •Acne

    Females

    •Deeper voice
    •Acne
    •Missed or irregular menstrual periods
    •Increased facial and body hair
    Common Side Effects for
    •Enlargement of male breasts
    •Pain or swelling at the implantation site

  • Warnings of Methyltestosterone vs. Testopel

    Common Side Effects for
    •Liver problems
    •Risk of blood clots, including heart attack or stroke
    •Potential for misuse, dependency, and addiction
    •Swelling in the legs or arms (edema)
    •High calcium in the blood
    •Fast bone maturation in children
    Common Side Effects for
    •Infection and extrusion at the implantation site
    •Risk of blood clots, including heart attack or stroke
    •Potential for misuse, dependency, and addiction
    •Prostate problems
    •Liver problems
    •Swelling in the legs or arms (edema)
    •High calcium in the blood
    •Sexual side effects
    •Fast bone maturation in children

  • Prices with our coupons for Methyltestosterone vs. Testopel

    Learn more about Methyltestosterone
    Learn more about Testopel

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