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Compare Methyltestosterone vs. Androderm

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Methyltestosterone (Methitest) and Androderm (testosterone patch) are both testosterone replacement therapies, but they have some key differences. Methyltestosterone is taken orally and is used to treat low testosterone in males, delayed puberty in boys, and breast cancer in females. It is available in a generic form, but it can cause serious liver side effects. Androderm, on the other hand, is a transdermal patch applied to the skin once a day to treat low testosterone in adult males. It has been discontinued in the United States, so you would need to look for alternative treatments. Androderm can cause skin irritation and requires rotating application sites to avoid rashes. Both medications are controlled substances due to the risk of misuse and dependency, but Androderm has a lower risk of accidentally exposing others to testosterone compared to gels.

  • Methyltestosterone (Methitest)
    Androderm (testosterone patch)
  • Methyltestosterone (Methitest)
    Androderm (testosterone patch)

  • Summary of Methyltestosterone vs. Androderm

    Summary for Testosterone replacement
    Prescription only

    Methyltestosterone (Methitest) is a pill form of testosterone used for testosterone replacement therapy (TRT) in males with low testosterone levels. It's also used to treat females with breast cancer that has spread to other parts of the body. The medication comes as a tablet or capsule and is typically taken by mouth once a day. Your dosage will depend on your condition and how you respond to treatment. Possible side effects include nausea, acne, and headaches.

    Summary for Testosterone replacement
    Prescription only

    Androderm (testosterone patch) is a testosterone replacement therapy that acts like the natural sex hormone testosterone. It raises testosterone levels in adult males who are diagnosed with low testosterone, also known as hypogonadism. Androderm (testosterone patch) is a patch that's applied to your skin once a day. Some common effects of this medication include skin irritation, itching, and burning.

    Please note: Androderm (testosterone patch) has been discontinued and is no longer available in the United States. Talk to your primary care provider about alternative testosterone replacement therapies available to treat low testosterone.

  • Indications of Methyltestosterone vs. Androderm

    Indications for

    Males

    •Low testosterone (hypogonadism)
    •Delayed puberty

    Females

    •Breast cancer that has spread to other parts of the body
    Indications for
    •Low testosterone levels in adult males (hypogonadism)

  • Pros and Cons of Methyltestosterone vs. Androderm

    Pros and Const for Testosterone replacement
    Pros
    •Is a pill taken by mouth
    •Restores healthy testosterone levels in men
    •Supports male development during puberty
    Cons
    •Risk of liver problems with long-term use
    •Potential for serious heart problems and blood clots
    •Risk of misuse and dependence since it's a controlled substance
    Pros and Const for Testosterone replacement
    Pros
    •Compared to testosterone gel, there’s a lower risk of accidentally exposing others to testosterone
    •Doesn't need to be removed during sex or while showering or bathing
    •Applied to your skin
    •Applied once a day
    Cons
    •Can cause skin irritation
    •Need to remember to rotate application sites every night
    •Heavy exercise or sweating too much might cause the patch to loosen or fall off
    •Need to wait 3 hours before you can shower, swim, or bathe

  • Common Side Effects of Methyltestosterone vs. Androderm

    Common Side Effects for

    Males

    •Breast enlargement
    •Acne

    Females

    •Deeper voice
    •Acne
    •Missed or irregular menstrual periods
    •Increased facial and body hair
    Common Side Effects for
    •Application site itchiness (17%)
    •Application site blisters (6%)
    •Back pain (6%)

  • Warnings of Methyltestosterone vs. Androderm

    Common Side Effects for
    •Liver problems
    •Risk of blood clots, including heart attack or stroke
    •Potential for misuse, dependency, and addiction
    •Swelling in the legs or arms (edema)
    •High calcium in the blood
    •Fast bone maturation in children
    Common Side Effects for
    •Higher red blood cell count and high risk of heart attack or stroke
    •Blood clots
    •Potential for misuse, dependency, and addiction
    •Worsening symptoms of enlarged prostate and prostate cancer
    •Liver problems
    •Low sperm count
    •Swelling in the legs or arms (edema)
    •Breathing problems during sleep (sleep apnea)
    •High calcium in the blood

  • Prices with our coupons for Methyltestosterone vs. Androderm

    Learn more about Methyltestosterone
    Learn more about Androderm

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