Key takeaways
Methyltestosterone (Methitest) and testosterone topical solution are both medications used for testosterone replacement therapy in males with low testosterone levels. However, they differ in several ways. Methyltestosterone is an oral medication available as a tablet or capsule, while testosterone topical solution is applied to the armpits. Methyltestosterone is also used to treat delayed puberty in males and breast cancer in females, whereas testosterone topical solution is only approved for low testosterone in males. Both medications are available as a lower-cost generic. Common side effects of methyltestosterone include acne and headaches, while testosterone topical solution most commonly causes application site irritation and headaches. Both medications carry risks of liver damage, heart problems, and blood clots. Because it's applied to the skin, testosterone topical solution may risk transferring the medication to others through skin contact, which is not a concern with methyltestosterone.
