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Xyosted vs. AndroGel

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Xyosted

(testosterone enanthate)

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testosterone gel

 

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Summary for Xyosted

Prescription only

Xyosted (testosterone enanthate) is a testosterone replacement therapy (TRT). It's used in adult males to treat low testosterone levels. It comes as an autoinjector for home use, allowing you to self-inject under the skin (subcutaneously) in the stomach once a week. Side effects can include headache and bruising at the injection site. Currently, it's only available as a brand-name medication since no generic version is available.

Indications for Xyosted

Pros and Cons for Xyosted

Pros

  • Available as a ready-to-use autoinjector, so you don't need to draw up the medication
  • Available in many different strengths
  • Only needs to be given once a week
  • Can be injected at home

Cons

  • Can cause high blood pressure, which can lead to serious heart conditions
  • Requires regular blood tests to monitor testosterone
  • Contains sesame oil, so not a good option if you have an allergy to sesame
  • Only available as a brand medication

Common Side Effects for Xyosted

  • High red blood cell count (14%)
  • High blood pressure (13%)
  • Rise in prostate-specific antigen (PSA, (12%)
  • Injection site bruising (7%)
  • Headache (5%)

Warnings for Xyosted

  • High blood pressure
  • Risk of blood clots, including heart attack or stroke
  • Prostate problems
  • Potential for misuse, dependency, and addiction
  • Liver problems
  • Swelling in the legs or arms (edema)
  • Sleep apnea
  • High calcium in the blood
  • Suicidal thoughts and behavior

Summary for AndroGel

Prescription only

Testosterone gel is a prescription topical medication used to treat men with low testosterone. It helps raise testosterone levels when your body doesn't make enough naturally. You typically apply it once a day to your skin. Depending on the product, the gel comes in packets, pumps, or tubes. Some side effects include skin irritation, mood changes, and headache.

Note: This medication is available under several brand names, including AndroGel, Testim, and Vogelxo as well as in generic versions. Each might have different strengths, application sites, and instructions.

Indications for AndroGel

Pros and Cons for AndroGel

Pros

  • Works well to raise testosterone levels
  • Applied once a day to your skin
  • Available in tubes, packets, or as a pump

Cons

  • Can cause skin irritation
  • Must avoid skin-to-skin transfer to other people
  • Need to wait hours before you can shower, swim, or bathe

Common Side Effects for AndroGel

AndroGel 1.62%

AndroGel 1%

  • Acne (1-8%)
  • Abnormal lab tests (3-6%)
  • Skin irritation (3-5%)
  • Prostate problems (3-5%)

Testim

  • Skin irritation (2-4%)
  • Rise in red blood cell count (1-2%)

Vogelxo

  • Skin irritation (2-4%)
  • Rise in red blood cell count (1-2%)

Warnings for AndroGel

  • Risk of testosterone gel spreading to others
  • Higher red blood cell count
  • Blood clots
  • Worsening of enlarged prostate and risk of prostate cancer
  • Higher blood pressure
  • Potential for misuse, addiction, and dependency
  • Lower sperm count
  • Liver problems
  • Swelling in the arms and legs (edema)
  • Enlarged breasts
  • Breathing problems during sleep (sleep apnea)
  • Changes in cholesterol levels
  • High calcium levels

Prices with our coupons for Xyosted vs. AndroGel

Price Card Drug Icon
Xyosted1 carton / 4 autoinjectors of 75mg
$437.21$795.59
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Price Card Drug Icon
Testosterone1 pump / 88g of 1.62%
$39.70$411.35
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