Key takeaways
Testosterone enanthate (Xyosted) and testosterone topical gel (AndroGel) are both used to treat low testosterone levels in men. However, they differ in their administration methods and availability. Xyosted comes in a prefilled injection pen that you'll use once a week, while testosterone gel is applied topically to the skin once a day. Xyosted is only available as a brand-name medication, whereas testosterone gel is available in both brand-name and lower-cost generic forms. Common side effects of Xyosted include high blood pressure and injection site bruising, while testosterone gel can cause skin irritation and mood changes. Both medications can lead to serious side effects such as heart attack and stroke. Testosterone gel also carries a risk of transferring to others through skin contact.
