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Compare Xyosted vs. Depo-Testosterone

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Xyosted (testosterone enanthate) and Depo-Testosterone (testosterone cypionate) are both testosterone replacement therapies used to treat low testosterone levels in adult males. They belong to the same drug class and are both controlled substances, classified as Schedule III due to their potential for misuse and dependency. However, they differ in their administration routes and dosing schedules. Xyosted is administered as a subcutaneous injection in the stomach once a week, while Depo-Testosterone is given as an intramuscular injection in the buttocks every 2 to 4 weeks. Xyosted is only available as a brand-name medication, whereas Depo-Testosterone has a lower-cost generic option. Common side effects of Xyosted include high blood pressure and injection site bruising, while Depo-Testosterone may cause enlargement of male breasts and acne. Both medications can interact with other drugs, but Xyosted specifically contains sesame oil, which may be a concern for those with allergies. Neither medication is recommended for males with breast or prostate cancer.

  • Xyosted (testosterone enanthate)
    Testosterone cypionate (Depo-Testosterone)
  • Xyosted (testosterone enanthate)
    Testosterone cypionate (Depo-Testosterone)

  • Summary of Xyosted vs. Depo-Testosterone

    Summary for Testosterone replacement
    Prescription only

    Xyosted (testosterone enanthate) is a testosterone replacement therapy (TRT). It's used in adult males to treat low testosterone levels. It comes as an autoinjector for home use, allowing you to self-inject under the skin (subcutaneously) in the stomach once a week. Side effects can include headache and bruising at the injection site. Currently, it's only available as a brand-name medication since no generic version is available.

    Summary for Testosterone replacement
    Prescription only

    Testosterone cypionate (Depo-Testosterone) is an injectable form of testosterone that’s used to treat low testosterone in adult males. It's injected into your buttock muscle and lasts for a long time, so it only needs to be used once or twice a month. But it might raise the risk of serious side effects including heart attack and stroke, especially if misused.

  • Indications of Xyosted vs. Depo-Testosterone

    Indications for
    •Low testosterone (hypogonadism)
    Indications for
    •Low testosterone (hypogonadism)

  • Pros and Cons of Xyosted vs. Depo-Testosterone

    Pros and Const for Testosterone replacement
    Pros
    •Available as a ready-to-use autoinjector, so you don't need to draw up the medication
    •Available in many different strengths
    •Only needs to be given once a week
    •Can be injected at home
    Cons
    •Can cause high blood pressure, which can lead to serious heart conditions
    •Requires regular blood tests to monitor testosterone
    •Contains sesame oil, so not a good option if you have an allergy to sesame
    •Only available as a brand medication
    Pros and Const for Testosterone replacement
    Pros
    •Only needs to be used once every 2 to 4 weeks
    •Can be injected at home
    •Comes in a vial that can be used for more than one dose, meaning fewer trips to the pharmacy
    •Available in as a lower-cost generic
    Cons
    •Risk of misuse, addiction, and dependency
    •Might raise the risk of serious side effects like heart attack and stroke if misused
    •Needs to be injected into the buttock muscle
    •Only available as an injection

  • Common Side Effects of Xyosted vs. Depo-Testosterone

    Common Side Effects for
    •High red blood cell count (14%)
    •High blood pressure (13%)
    •Rise in prostate-specific antigen (PSA, (12%)
    •Injection site bruising (7%)
    •Headache (5%)
    Common Side Effects for
    •Enlargement of male breasts
    •Acne
    •Pain at the injection site

  • Warnings of Xyosted vs. Depo-Testosterone

    Common Side Effects for
    •High blood pressure
    •Risk of blood clots, including heart attack or stroke
    •Prostate problems
    •Potential for misuse, dependency, and addiction
    •Liver problems
    •Swelling in the legs or arms (edema)
    •Sleep apnea
    •High calcium in the blood
    •Suicidal thoughts and behavior
    Common Side Effects for
    •Potential for misuse, addiction, and dependency
    •Heart attack and stroke risk
    •Blood clots
    •Liver problems
    •Use in people with an enlarged prostate
    •Swelling in the arms and legs (edema)
    •High calcium in the blood
    •Use in young children

  • Prices with our coupons for Xyosted vs. Depo-Testosterone

    Learn more about Xyosted
    Learn more about Testosterone cypionate

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