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Xyosted Coupon - Xyosted 4 autoinjectors of 75mg carton

Xyosted

testosterone enanthate
Used for Testosterone Replacement
Used for Testosterone Replacement

Xyosted (testosterone enanthate) is a testosterone replacement therapy (TRT). It's used in adult males to treat low testosterone levels. It comes as an autoinjector for home use, allowing you to self-inject under the skin (subcutaneously) in the stomach once a week. Side effects can include headache and bruising at the injection site. Currently, it's only available as a brand-name medication since no generic version is available.

Last reviewed on August 8, 2024
Xyosted (testosterone enanthate) is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
basics-icon

What is Xyosted (testosterone enanthate)?

What is Xyosted (testosterone enanthate) used for?

How Xyosted (testosterone enanthate) works

Xyosted (testosterone enanthate) is a testosterone replacement therapy that acts like the natural sex hormone, testosterone. Testosterone is responsible for the development and maintenance of many male features and functions, such as muscle and bone strength and growth, regulating sex drive, and sperm production. Xyosted (testosterone enanthate) works by raising testosterone to normal and healthy levels in males with low testosterone.

Are you looking for information on testosterone enanthate intramuscular injection instead?
When does Xyosted (testosterone enanthate) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsXyosted
Drug ClassTestosterone replacement
Controlled Substance ClassificationSchedule III
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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$777.36(save 79.92%)
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What are the risks and warnings for Xyosted (testosterone enanthate)?

Xyosted (testosterone enanthate) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

risk-warning

High blood pressure

  • Risk factors: History of heart problems

    Xyosted (testosterone enanthate) can cause high blood pressure that can raise the risk of serious problems, such as heart attack, stroke, and sudden heart-related death. This is more likely to occur in people who already have heart problems. If you develop high blood pressure, you might need to start a new medication to lower it, or adjust your current blood pressure medication. If it continues to remain high, stopping Xyosted (testosterone enanthate) might be necessary. Your prescriber will regularly monitor your blood pressure before and during your treatment with this medication.

    risk-warning

    Risk of blood clots, including heart attack or stroke

    • Risk factors: History of heart conditions

      Taking testosterone replacement therapy, like Xyosted (testosterone enanthate), can raise your risk of blood clots. This can lead to problems such as strokes and heart attacks. Your healthcare team will have you perform regular blood tests, called the complete blood count (CBC), to check that your blood cell counts are in the safe range. Get emergency help right away if you have chest pain, cold sweats, left arm pain, difficulty breathing, trouble walking, trouble speaking, or weakness on one side of the body, since you might have to stop taking the medication.

      risk-warning

      Prostate problems

      • Risk factors: History of enlarged prostate

        Taking Xyosted (testosterone enanthate) can worsen certain symptoms in people with an enlarged prostate, or benign prostatic hyperplasia (BPH). Let your prescriber know if you experience any changes in your urinary routine, such as more urination at night, feeling like you need to urinate more often or immediately, trouble urinating, accidentally urinating, or urinating slowly.

        Xyosted (testosterone enanthate) can also raise your risk of prostate cancer. Your prescriber might have you perform occasional blood tests and physical check-ups before and during treatment with this medication.

        risk-warning

        Potential for misuse, dependency, and addiction

        • Risk factors: Taking more Xyosted (testosterone enanthate) than prescribed | Taking Xyosted (testosterone enanthate) with other testosterones

          Xyosted (testosterone enanthate) is a controlled substance because it has a risk of misuse and dependency, especially if you use higher doses than prescribed or use it with other testosterones.

          Continued misuse of Xyosted (testosterone enanthate) can lead to addiction. The FDA has only approved this medication for the treatment of low testosterone in males. Taking Xyosted (testosterone enanthate) for other reasons can lead to serious side effects, such as heart attack, heart failure, stroke, depression, hallucinations, and delusions. Only take this medication as prescribed by your healthcare professional.

          risk-warning

          Liver problems

          Using certain forms of testosterone, such as methyltestosterone and testosterone enanthate intramuscular injection, for long periods of time can cause life-threatening liver problems. This isn't a known risk of Xyosted (testosterone enanthate), but it's important to look out for signs and symptoms of liver damage. Let your prescriber know if you're experiencing stomach pain, light-colored stools, dark urine, or if your skin or the whites of your eyes turn yellow, because you might need to stop the medication.

          risk-warning

          Swelling in the legs or arms (edema)

          • Risk factors: History of heart, liver, or kidney conditions | Taking other medications that cause swelling like corticosteroids

            Xyosted (testosterone enanthate) can cause your body to hold onto more salt and water, which can lead to swelling in your legs or arms and sudden weight gain. This is more likely to happen if you're taking other medications that cause swelling, such as corticosteroids (e.g., prednisone, methylprednisolone (Medrol)). It can be more serious in people with heart, liver, or kidney conditions. Talk to your prescriber if you have any of these symptoms, because you might need to stop the medication.

            risk-warning

            Sleep apnea

            • Risk factors: History of sleep apnea | Obesity | History of lung disease

              Xyosted (testosterone enanthate) can cause sleep apnea, a condition in which you stop breathing for short periods of time while sleeping. This is more likely to happen to people who also identify as obese or have lung problems. If you experience more daytime sleepiness or if your partner notices that you stop breathing in your sleep more often, talk to your prescriber.

              risk-warning

              High calcium in the blood

              • Risk factors: History of cancer | Taking other medications that cause high calcium in the blood

                Xyosted (testosterone enanthate) can cause high calcium in the blood (hypercalcemia), especially in people with cancer. For people with cancer, high calcium levels might be a sign that the cancer has spread to the bones. During treatment with Xyosted (testosterone enanthate), your prescriber might have you perform regular blood tests to make sure your calcium levels are within a safe range.

                risk-warning

                Suicidal thoughts and behavior

                • Risk factors: History of depression | History of other mental health conditions

                  Xyosted (testosterone enanthate) can cause new or worsening depression, suicidal thoughts and behavior, anxiety, or other mental health changes that can be dangerous. Symptoms can include feeling sad or hopeless, losing interest in activities that once made you happy, changes in appetite, tiredness, trouble sleeping, and feeling worthless. If you or anyone around you notice any changes in your thoughts or behavior, let your prescriber know right away. You might need to stop taking the medication.

                  basics-icon

                  What are the side effects of Xyosted (testosterone enanthate)?

                  The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

                  Common Side Effects

                  • High red blood cell count (14%)
                  • High blood pressure (13%)
                  • Rise in prostate-specific antigen (PSA, (12%)
                  • Injection site bruising (7%)
                  • Headache (5%)

                  Other Side Effects

                  • Injection site bleeding
                  • Injection site redness
                  • Acne
                  • Cough
                  • Nausea
                  • Fatigue
                  • Swelling of the arms and legs
                  • Urinary tract infection
                  • Blood in the urine
                  • Stomach pain
                  • Back pain
                  • Joint pain
                  • Muscle damage
                  • Sleep apnea
                  • Trouble sleeping
                  • Erections lasting a long time

                  Serious Side Effects

                  Contact your healthcare provider immediately if you experience any of the following.
                  • High blood pressure
                  • Heart attack: chest pain, cold sweats, left arm pain, difficulty breathing
                  • Stroke: face drooping, trouble seeing, walking, or speaking, weakness on one side of the body
                  • Blood clot in the legs: pain, swelling, warm to touch, redness
                  • Blood clot in the lungs: trouble breathing, chest pain, cough
                  • Liver damage: stomach pain, nausea, vomiting, yellowing of the skin, yellowing of the whites of the eyes, light-colored stools, dark urine, weight loss
                  • Withdrawal: depression, fatigue, craving, restlessness, irritability, lack of appetite, trouble sleeping (insomnia), lowered sex drive, low testosterone
                  • Suicidal thoughts and behaviors
                  When do Xyosted (testosterone enanthate) possible side effects begin and end?
                  Time passed since treatment started:
                  MINUTES
                  HOURS
                  DAYS
                  WEEKS
                  MONTHS
                  High red blood cell count
                  Rise in PSA
                  Injection site reactions
                  High blood pressure
                  Seek immediate medical care if you experience this side effect.
                  If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

                  Source: DailyMed

                  The following side effects have also been reported

                  Discuss these possible effects with your doctor:

                  Tumors of the liver, liver cancer, or peliosis hepatis (a form of liver disease) have occurred during long-term, high-dose therapy with androgens. Although these effects are rare, they can be very serious and may cause death.

                  Androgens can stimulate existing prostate cancer in men who already have it but have not yet been diagnosed. Also, the prostate (a male gland) may become enlarged. Enlargement of the prostate does not mean that cancer will develop. If enlargement occurs and you have difficulty in urinating, it is a good idea to be checked by your doctor.

                  When androgens are used in women, especially in high doses, male-like changes may occur, such as hoarseness or deepening of the voice, unnatural hair growth, or unusual hair loss. Most of these changes will go away if the medicine is stopped as soon as the changes are noticed. However, some changes, such as voice changes or enlarged clitoris, may not go away.

                  When androgens are used in high doses in males, they interfere with the production of sperm. This effect is usually temporary and only happens during the time you are taking the medicine. However, discuss this possible effect with your doctor if you are planning on having children.

                  Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

                  Check with your doctor immediately if any of the following side effects occur:

                  More common

                  For females only

                  Acne or oily skin

                  decreased breast size

                  irregular menstrual cycles

                  hoarseness or deepening of voice

                  increase in size of female genitals

                  increase in unnatural hair growth or male pattern baldness

                  These symptoms may occur in females whose male sexual partner uses a scrotal patch.

                  For males only

                  Blistering of skin under patch (especially when the nonscrotal patch is applied to bony areas of the skin)

                  breast soreness or enlargement

                  frequent or continuing erection of penis lasting up to 4 hours or painful penile erections lasting longer than 4 hours

                  frequent urge to urinate

                  itching or redness of skin under patch (less likely with nonscrotal patch) or at site of implants, mild to severe

                  For prepubertal boys only

                  Acne

                  early growth of pubic hair

                  enlargement of penis

                  frequent or continuing erections

                  Less common

                  For males or females

                  Dizziness

                  frequent or continuing headache

                  lack or loss of strength

                  nausea

                  overall body flushing, redness, or itching of skin

                  rapidly changing moods, such as depersonalization, dysphoria, euphoria, depression, paranoia, and quick to react or overreact emotionally

                  swelling of feet or lower legs

                  unusual bleeding

                  unusual tiredness

                  yellow skin or eyes (occurring with fluoxymesterone or methyltestosterone more often than with testosterone)

                  For females with breast cancer or bedridden males or females—in addition to the side effects listed above

                  Confusion or mental depression

                  constipation

                  increased thirst

                  increased urge to urinate or increased amount of urine

                  For males only

                  Black, tarry stools

                  burning sensation or hardening or thickening of skin under patch

                  chills

                  continuing pain at site of implants

                  difficulty in urinating

                  itching, skin redness, or rash under patch, severe (less likely with nonscrotal patch)

                  pain in scrotum or groin

                  vomiting of blood or material that looks like coffee grounds

                  Rare

                  For males or females—more likely with oral androgens or long-term or high doses of androgens

                  Abdominal or stomach pain, continuing

                  bad breath odor, continuing

                  black, tarry or light-colored stools or dark urine

                  fever

                  hives

                  loss of appetite, continuing

                  mood or mental changes

                  purple or red spots on body or inside the mouth or nose

                  sore throat

                  swelling, pain, or tenderness of abdomen

                  vomiting of blood

                  Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

                  Less common

                  For males and females

                  Acne, mild

                  decrease or increase in sexual desire or drive

                  diarrhea

                  hair loss or thinning of hair

                  increase in pubic hair growth

                  infection, pain, redness, or other irritation at site of injection

                  nervousness

                  stomach pain

                  trouble in sleeping

                  For males only

                  Decrease in testicle size

                  infection, pain, redness, swelling, sores, or other skin irritation underneath patch

                  Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

                  Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

                  pros-and-cons

                  Pros and cons of Xyosted (testosterone enanthate)

                  thumbs-up

                  Pros

                  Available as a ready-to-use autoinjector, so you don't need to draw up the medication

                  Available in many different strengths

                  Only needs to be given once a week

                  Can be injected at home

                  thumbs-down

                  Cons

                  Can cause high blood pressure, which can lead to serious heart conditions

                  Requires regular blood tests to monitor testosterone

                  Contains sesame oil, so not a good option if you have an allergy to sesame

                  Only available as a brand medication

                  pharmacist-tips

                  Pharmacist tips for Xyosted (testosterone enanthate)

                  pharmacist
                  • You might want to check your blood pressure at home while taking Xyosted (testosterone enanthate). That's because the medication can raise your blood pressure, potentially leading to serious side effects such as heart attack and stroke.

                    • Xyosted (testosterone enanthate) can often cause the breast area in males to become bigger, painful, or tender. This might continue throughout treatment with this medication. Let your prescriber know if this becomes bothersome.

                      • Xyosted (testosterone enanthate) can lower sperm count. This might affect your ability to have a baby and raise the risk for infertility. Let your healthcare team know if you're thinking of having a baby before you start this medication so they can talk with you about family planning options.

                        • After injecting Xyosted (testosterone enanthate), remember to place the used injector in a sharps container to avoid injury. Check with your local waste removal company or health department to find out where to dispose of the sharps container safely.

                          • Store Xyosted (testosterone enanthate) at room temperature. Don't refrigerate or freeze the medication. Keep the medication in the box until you are ready to use it so that it's protected from light.

                            How to use Xyosted (testosterone enanthate)

                            • Carefully read and follow the instructions for use before your first injection. Ask your prescriber or pharmacist if you have questions on how to inject the medication correctly.

                              • When you're ready to inject, use your fingers to gently pinch an area of your stomach, and keep pinching until you finish injecting. With your other hand, press the injector firmly against the pinched area until you hear a click. Hold it there for 10 seconds.

                                • After you inject the medication, make sure the viewing window on the injector has turned orange.

                                  faqs

                                  Frequently asked questions about Xyosted (testosterone enanthate)

                                  Does Xyosted (testosterone enanthate) cause weight gain?
                                  Weight gain isn't a reported side effect of Xyosted (testosterone enanthate). But it can cause swelling and fluid build up in the arms and legs, which might contribute to weight gain. Let your prescriber know if you have any questions about this medication and weight gain.
                                  How long does it take Xyosted (testosterone enanthate) to work?
                                  Xyosted (testosterone enanthate) should work soon after taking the medication. Although your body fully absorbs the medication in about 12 hours, it can take 6 weeks before your testosterone levels stabilize. But because your dose can't be adjusted until your levels stabilize, finding the right dose that works for you might take several months.
                                  How well does Xyosted (testosterone enanthate) work?
                                  In a clinical trial, about 93% of people taking Xyosted (testosterone enanthate) had normal testosterone levels after 12 weeks. Discuss with your prescriber about how well this medication might work for you.
                                  Does Xyosted (testosterone enanthate) need to be refrigerated?
                                  No. Xyosted (testosterone enanthate) should be stored and used at room temperature. In fact, avoid storing the medication in the refrigerator and protect it from light.
                                  Is Xyosted (testosterone enanthate) a controlled substance?
                                  Yes. Testosterones like Xyosted (testosterone enanthate) are controlled substances, specifically categorized as schedule III. That's because there's a risk for misuse, dependency, and addiction, especially at higher doses. That's why it's important to only take this medication as prescribed. Discuss with your prescriber if you have concerns about taking Xyosted (testosterone enanthate).
                                  Where do you inject Xyosted (testosterone enanthate)?
                                  Xyosted (testosterone enanthate) should be injected under the skin in the stomach, at least 2 inches away from your belly button. To lessen skin irritation and to make sure that the medication is fully absorbed, avoid injecting in areas where your skin is tender, bruised, red, or has scars, tattoos, or stretch marks. Also don't inject the medication in a muscle or a vein, because your body won't absorb the medication properly, so it won't work as well.
                                  Which dosage form does Xyosted Xyosted (testosterone enanthate) come in?
                                  Xyosted (testosterone enanthate) is available as a subcutaneous autoinjector. This means you self inject the medication under the skin.
                                  What's the difference between Xyosted (testosterone enanthate) autoinjector and testosterone enanthate intramuscular injection?
                                  Xyosted (testosterone enanthate) autoinjector and testosterone enanthate intramuscular injection are both injectable testosterone medications used to treat low testosterone in males, but they have differences in how they're given. Xyosted (testosterone enanthate) is an injection that's given under the skin of your stomach once a week, while intramuscular testosterone enanthate is injected into your buttock muscle once or twice a month. These medications need to be injected into these specific areas of the body so that they are fully absorbed to work.
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                                  dosage

                                  Xyosted (testosterone enanthate) dosage forms

                                  The average cost for 1 carton of 4 autoinjectors of 75mg of Xyosted (testosterone enanthate) is $451.29 with a free GoodRx coupon. This is 41.95% off the average retail price of $777.36.
                                  autoinjector
                                  Autoinjector
                                  DosageQuantityPrice as low asPrice per unit
                                  50mg4 autoinjectors$156.07$39.02
                                  75mg4 autoinjectors$160.27$40.07
                                  100mg4 autoinjectors$160.26$40.06
                                  carton
                                  Carton
                                  DosageQuantityPrice as low asPrice per unit
                                  4 autoinjectors of 50mg1 carton$451.29$451.29
                                  4 autoinjectors of 75mg1 carton$451.29$451.29
                                  4 autoinjectors of 100mg1 carton$451.29$451.29

                                  Typical dosing for Xyosted (testosterone enanthate)

                                  The typical starting dose is 75 mg injected once a week under the skin in the stomach. Your prescriber might change the dose based on your testosterone levels in the blood.

                                  interactions

                                  Interactions between Xyosted (testosterone enanthate) and other drugs

                                  Xyosted (testosterone enanthate) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Xyosted (testosterone enanthate). Please note that only the generic name of each medication is listed below.

                                  Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

                                  Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

                                  Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                  drug-cost

                                  How much does Xyosted (testosterone enanthate) cost?

                                  To access savings, use a GoodRx coupon and pay just a fraction of the retail price.View prices & coupons
                                  contraindications-icon

                                  Xyosted (testosterone enanthate) contraindications

                                  Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Xyosted (testosterone enanthate) will not be safe for you to take.
                                  • Males with breast cancer or prostate cancer

                                  • Females who are pregnant

                                  • Males with low testosterone due to other reasons

                                  alternatives

                                  What are alternatives to Xyosted (testosterone enanthate)?

                                  There are a number of medications that your doctor can prescribe in place of Xyosted (testosterone enanthate). Compare a few possible alternatives below.
                                  Xyosted (testosterone enanthate)
                                  $156.07 Lowest GoodRx priceView Prices
                                  Used for:
                                  $32.44 Lowest GoodRx priceView Prices
                                  Used for:
                                  $551.85 Lowest GoodRx priceView Prices
                                  images

                                  Xyosted (testosterone enanthate) images

                                  yellow - XYOSTED 75mg / 0.5mL Anto-Injector Solution for Injection
                                  This medicine is Yellow Carton.yellow - XYOSTED 75mg / 0.5mL Anto-Injector Solution for Injection

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                                  References

                                  Best studies we found
                                  View All References (4)

                                  Sizar, O., et al. (2024). Male hypogonadism.

                                  U.S. Food and Drug Administration. (2021). Sharps disposal containers.

                                  Yamaguchi, A. V., et al. (2019). Testosterone replacement therapy and the risk of hypoglycemia. Case Reports in Endocrinology.

                                  You and Your Hormones. (2020). Testosterone.

                                  GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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