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Compare Testopel vs. Delatestryl

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Testopel (testosterone) and testosterone enanthate (Delatestryl) are both testosterone replacement therapies used to treat low testosterone levels (hypogonadism) and delayed puberty in males. They belong to the same drug class and work by increasing testosterone levels. However, they differ in their administration and additional uses. Testopel is an implantable pellet placed under the skin by a healthcare professional every 3 to 6 months, while testosterone enanthate is an intramuscular injection given by a healthcare professional every 2 to 4 weeks. Testosterone enanthate is also FDA-approved for treating metastatic breast cancer in females, which is not an indication for Testopel. Testopel is only available as a brand-name medication, whereas testosterone enanthate is available in a lower-cost generic form. Common side effects of both medications include acne as well as pain and swelling at the implantation or injection site. Both medications increase the risk of serious side effects like heart attack and liver problems, and they can interact with blood thinners, increasing the risk of bleeding.

  • Testopel (testosterone pellets)
    Testosterone enanthate
  • Testopel (testosterone pellets)
    Testosterone enanthate

  • Summary of Testopel vs. Delatestryl

    Summary for Testosterone replacement
    Prescription only

    Testopel (testosterone pellets) is an implantable pellet medication used as long-acting testosterone replacement therapy. It treats certain males with low testosterone and delayed puberty. The pellets are implanted, or placed under your skin, by a healthcare professional (HCP) typically every 3 to 6 months. Side effects include pain and swelling at the implantation site, as well as sexual side effects like more frequent erections and changes in sex drive.

    Summary for Testosterone replacement
    Prescription only

    Testosterone enanthate is a testosterone replacement therapy. It's mainly used in males to treat low testosterone levels and delayed puberty. It's also FDA-approved in females for treating metastatic breast cancer, but it's not a first-choice option for this condition. Testosterone enanthate is given as a deep injection into the muscle of the buttock, typically every 2 to 4 weeks by a healthcare professional (HCP). Side effects can include acne and pain or swelling at the injection site.

  • Indications of Testopel vs. Delatestryl

    Indications for
    •Low testosterone (hypogonadism)
    •Delayed puberty
    Indications for
    •Low testosterone (hypogonadism) in males
    •Delayed puberty in males
    •Metastatic breast cancer that have spread to the bones in females who've started menopause in the past 1 to 5 years

  • Pros and Cons of Testopel vs. Delatestryl

    Pros and Const for Testosterone replacement
    Pros
    •A long-acting testosterone replacement medication
    •Implanted every 3 to 6 months
    •Can be used in children and adults
    •Unlike testosterone gel, there’s no risk of accidentally exposing others to testosterone
    Cons
    •Can cause pain and swelling at the implantation site
    •Risk of infections or extrusions at the implantation site
    •Is a surgical procedure that must be done at the prescriber's office
    •Dose adjustments are difficult since they require surgical removal or addition of pellets
    Pros and Const for Testosterone replacement
    Pros
    •Starts to work in 1-3 days to raise testosterone levels
    •Only needs to be used once every 2 to 4 weeks
    •Can be injected at home for some people
    •Available in a lower-cost, generic form
    Cons
    •In females, can cause the development of male features, including deepening of the voice, acne, absence of menstrual periods, and more facial and body hair
    •Needs to be injected into the buttock muscle
    •Only available as an injection
    •Contains sesame oil, so might not be a good option if you have an allergy to sesame

  • Common Side Effects of Testopel vs. Delatestryl

    Common Side Effects for
    •Enlargement of male breasts
    •Pain or swelling at the implantation site
    Common Side Effects for

    Males

    •Enlargement of male breasts
    •Acne
    •More erections
    •Pain at the injection site

    Females

    •Deepening of the voice
    •Acne
    •Absence of or irregular menstrual periods
    •More hair on the face and body
    •Pain at the injection site

  • Warnings of Testopel vs. Delatestryl

    Common Side Effects for
    •Infection and extrusion at the implantation site
    •Risk of blood clots, including heart attack or stroke
    •Potential for misuse, dependency, and addiction
    •Prostate problems
    •Liver problems
    •Swelling in the legs or arms (edema)
    •High calcium in the blood
    •Sexual side effects
    •Fast bone maturation in children
    Common Side Effects for
    •Risk of blood clots, including heart attack or stroke
    •Prostate problems
    •Potential for misuse, dependency, and addiction
    •Liver problems
    •Low sperm count
    •Swelling in the legs or arms (edema)
    •High calcium levels in the blood
    •Fast bone maturation in children
    •Severe allergic reactions

  • Prices with our coupons for Testopel vs. Delatestryl

    Learn more about Testopel
    Learn more about Testosterone enanthate

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