Key takeaways
Alli, Xenical (orlistat) and Saxenda (liraglutide) are both used to help with weight loss, but they work in different ways and are taken differently. Orlistat is an enzyme that blocks the absorption of fats from the foods you eat and is taken three times daily. It's available both over-the-counter (Alli) and by prescription (Xenical). On the other hand, Saxenda is a glucagon-like peptide-1 (GLP-1) receptor agonist that makes you feel less hungry by slowing down your digestion. It's injected once daily under the skin and is only available with a prescription. Orlistat can cause side effects like oily stools and gas, while Saxenda can cause nausea and vomiting. Additionally, Saxenda has a risk of low blood sugar (hypoglycemia), especially if taken with insulin, which orlistat does not have. Both medications work best when combined with a well-balanced diet and increase physical activity.
