Key takeaways
Vivelle-Dot (estradiol patch) and Evamist (estradiol spray) are both estrogen replacement therapies used to treat menopause symptoms like hot flashes and night sweats. They are in the same medication class and work by replacing estrogen that your body loses during menopause. However, they differ in their forms and specific uses. Vivelle-Dot is a transdermal patch applied twice a week, while Evamist is a topical spray applied to your inner forearm once daily. Vivelle-Dot is also used for preventing osteoporosis after menopause, which is not an FDA-approved use for Evamist. Vivelle-Dot is available as a generic called Dotti, but Evamist does not have a generic version. Common side effects for both include headaches, common cold symptoms, and breast tenderness. Both medications can increase the risk of blood clots and certain types of cancer.
