Key takeaways
Viibryd (vilazodone) and Zoloft (sertraline) are both medications used to treat major depressive disorder (MDD), but they have some key differences. Viibryd is a combination selective serotonin reuptake inhibitor (SSRI) and a serotonin (5HT1A) receptor partial agonist, while Zoloft is a traditional SSRI. This means Viibryd not only increases serotonin levels but also directly acts on serotonin receptors. Zoloft is approved to treat a wider range of mental health disorders, including obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder, whereas Viibryd only treats MDD. Both medications are taken once daily and are available in generic forms. Common side effects for Viibryd include diarrhea, nausea, and headache, while Zoloft commonly causes nausea, diarrhea, and dry mouth. Viibryd is less likely to cause weight gain and sexual side effects compared to Zoloft. Both medications can cause withdrawal symptoms if stopped suddenly, so it's important to follow your healthcare provider's instructions when discontinuing use.
