Key takeaways
Velphoro (sucroferric oxyhydroxide) and Renagel (sevelamer hydrochloride) are both phosphate binders used to lower high blood phosphate levels in people with chronic kidney disease on dialysis. Velphoro is a chewable tablet with a berry flavor, while Renagel is a large tablet that must be swallowed whole. Velphoro is taken three times a day with meals, and its iron content can cause dark stools and discolored teeth. Renagel, on the other hand, is also taken with meals but is not suitable for people with swallowing or severe constipation issues. Renagel is calcium-free, which helps avoid high calcium levels, and may also benefit those with high cholesterol. Velphoro can interact with medications like levothyroxine and doxycycline, while Renagel can cause serious digestive issues, including bowel blockage. Renagel is available in a generic form, which may be more affordable.
