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Renvela vs. Fosrenol

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Sevelamer carbonate (Renvela) and lanthanum (Fosrenol) are both phosphate binders used to lower blood phosphate levels in people with kidney disease. Sevelamer carbonate is available as a tablet and a powder, while lanthanum comes as a tablet that must be chewed or crushed before taking as well as a powder that can be mixed with food. Sevelamer carbonate and lanthanum are available as a lower-cost generic, but lanthanum generally tends to be more expensive. Both medications must be taken with meals to work effectively. Sevelamer carbonate and lanthanum can cause digestive tract blockages and other digestive issues such as nausea and vomiting. Additionally, lanthanum can also show up on abdominal X-rays, which is something to keep in mind if you need an abdominal X-ray done. This is not a concern with sevelamer carbonate.

Sevelamer carbonate

(Renvela)

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Lanthanum

(Fosrenol)

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Summary for Renvela

Prescription only

Sevelamer carbonate (Renvela) is a medication that's used to lower blood phosphate levels in people ages 6 years and older with chronic kidney disease (CKD) on dialysis. It's common to have stomach side effects, like nausea, vomiting, diarrhea, and stomach pain, with this medication. Sevelamer carbonate (Renvela) is available as a tablet that's swallowed whole and as a powder that can be made into a liquid (suspension). Both formulations are available as lower-cost generics.

Indications for Renvela

  • High blood phosphate levels in people ages 6 years and older with chronic kidney disease (CKD) on dialysis

Pros and Cons for Renvela

Pros

  • Works well to lower blood phosphate levels
  • Available as a powder that can be made into a liquid for people who have trouble swallowing pills
  • Available as a lower-cost generic

Cons

  • Must take with meals for it to work
  • Not the first choice for people with swallowing or constipation problems
  • Might have interactions with some medications, such as ciprofloxacin (Cipro), that require specifically timed separation from sevelamer carbonate (Renvela)

Common Side Effects for Renvela

  • Vomiting (22%)
  • Nausea (20%)
  • Diarrhea (19%)
  • Indigestion (16%)
  • Stomach pain (9%)
  • Feeling gassy (8%)
  • Constipation (8%)

Warnings for Renvela

  • Blockage of your digestive tract
  • Low levels of vitamin D, E, and K and folic acid

Summary for Fosrenol

Prescription only

Lanthanum (Fosrenol) works well to lower phosphorus levels in the blood without affecting calcium levels in people with advanced kidney disease, but it can be expensive and you need to take it with meals.

Indications for Fosrenol

  • High blood phosphate levels in advanced kidney disease

Pros and Cons for Fosrenol

Pros

  • Works as well as other phosphate binders to lower blood phosphate levels
  • Easy to take since lanthanum (Fosrenol) comes in powder form, and the tablet form can be crushed or chewed
  • Calcium-free, which means lanthanum (Fosrenol) doesn't come with the risk of high calcium levels like some other phosphate binders

Cons

  • Like other phosphate binders, lanthanum (Fosrenol) must be taken with meals.
  • More expensive than other phosphate binders
  • Not a good option for people with certain bowel disorders, serious liver disease, or who have trouble chewing or crushing tablets (tablet form only)

Common Side Effects for Fosrenol

  • Nausea (11%)
  • Vomiting (9%)
  • Belly pain (5%)

Warnings for Fosrenol

  • Blockage of your digestive tract
  • Interference with X-rays

Prices with our coupons for Renvela vs. Fosrenol

Price Card Drug Icon
Sevelamer Carbonate90 tablets / 800mg
$30.99-
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Lanthanum90 chewable tablets / 1000mg
$154.28$1,000.07
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