Key takeaways
Calcitriol (Rocaltrol) and paricalcitol (Zemplar) are both vitamin D analogs used to manage conditions related to calcium and parathyroid hormone (PTH) levels, but they have different primary uses and dosing schedules. Calcitriol is mainly used to raise blood calcium levels in people with kidney and parathyroid problems, while paricalcitol is used to lower PTH levels in people with chronic kidney disease (CKD). Calcitriol is taken daily, whereas paricalcitol can be taken either daily or three times a week. Both medications require regular blood tests to monitor calcium and other levels, but paricalcitol also necessitates dietary adjustments to manage phosphorus intake. Additionally, while both medications can cause high calcium levels, paricalcitol has a broader range of potential side effects, including high blood pressure and dizziness. Both medications are available in generic forms, making them more affordable options.
