Compare Velphoro vs. PhosLo

Velphoro (sucroferric oxyhydroxide) and calcium acetate are both phosphate binders used to lower phosphate levels in people with chronic kidney disease (CKD) on dialysis, but they have some key differences. Velphoro is a chewable tablet with a berry flavor, while calcium acetate comes in capsules and tablets that must be swallowed whole. Velphoro works by binding to phosphates in your food. One tablet is taken with each meal taken, whereas calcium acetate is typically taken as two pills with each meal. One major difference is that Velphoro can cause dark stools and discolored teeth, while calcium acetate can raise your blood calcium levels. This can lead to potential side effects like nausea and vomiting. Additionally, Velphoro may interact with medications like levothyroxine and doxycycline, while calcium acetate can interact with digoxin and other calcium-containing products. Velphoro is easier to chew compared to some other phosphate binders, but calcium acetate is available as a lower-cost generic option.