Key takeaways
Velphoro (sucroferric oxyhydroxide) and Fosrenol (lanthanum) are both phosphate binders used to lower high blood phosphate levels in people with advanced kidney disease on dialysis. Velphoro is a chewable tablet with a berry flavor, while Fosrenol can be taken as a chewable tablet or in powder form mixed with food. Both medications are typically taken three times a day with meals and the tablets must be chewed or crushed. Velphoro can cause dark stools and discolored teeth, whereas Fosrenol may lead to nausea, vomiting, and belly pain. Additionally, Fosrenol is more expensive and can cause digestive tract blockages, which is a risk not mentioned for Velphoro. Both medications interact with other drugs, but Fosrenol specifically requires spacing out from antacids, certain antibiotics, and thyroid medications by two hours.
