Key takeaways
Hectorol (doxercalciferol) and Zemplar (paricalcitol) are both vitamin D analogs used to lower parathyroid hormone (PTH) levels in people with chronic kidney disease (CKD). While both medications are available in lower-cost generic forms and can be taken orally or through IV injections, there are some differences between them. Hectorol (doxercalciferol) is only approved for use in adults, whereas Zemplar (paricalcitol) can also be used in children as young as 10 years old. Additionally, Hectorol (doxercalciferol) is typically taken once a day or three times a week, depending on the stage of CKD, and Zemplar (paricalcitol) can also be taken once a day or three times a week, with specific dosing for children. Both medications require regular lab work to monitor calcium and PTH levels, but Zemplar (paricalcitol) also necessitates monitoring phosphorus levels. Side effects for both include high calcium levels, infections, nausea, and constipation.
