Key takeaways
Topiramate (Topamax, Qudexy XR, Trokendi XR, Eprontia) and zonisamide (Zonegran) are both antiepileptic medications, but they have some key differences. Topiramate can be used alone or with other medications to treat various types of seizures and to prevent migraines, while zonisamide is only used with other medications to control partial-onset seizures. Topiramate is available in multiple forms, including immediate-release and extended-release tablets, capsules, and a liquid solution, whereas zonisamide comes as capsules and an oral suspension. Topiramate can be used in children as young as 2 years old for seizures, but zonisamide is only approved for people aged 16 and older. Both medications can cause higher acid levels in the blood, have risks associated with pregnancy, and can lead to serious eye problems. However, topiramate is known to interact with more medications compared to zonisamide. Both medications are available as a lower-cost generic.
