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Topamax vs. Dilantin

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Topiramate (Topamax, Qudexy XR, Trokendi XR, Eprontia) and phenytoin (Dilantin) are both antiepileptic medications used to treat seizures, but they have some key differences. Topiramate can be used alone or with other medications to treat various types of seizures and to prevent migraines, while phenytoin is only used for treating and preventing seizures. Topiramate is available in multiple forms, including tablets, capsules, and a liquid solution, and can be taken once or twice daily. In contrast, phenytoin is available as capsules, chewable tablets, and liquid, and typically requires multiple doses per day. Both medications can cause serious side effects, with topiramate increasing the risk for causing kidney stones and vision problems and phenytoin can lead to heart problems and liver damage. Additionally, both medications can affect birth control effectiveness and pose risks during pregnancy, including birth defects. Your healthcare professional may order periodic tests to measure the blood levels of these medications and monitor potential side effects.

Topiramate

(Topamax)

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Phenytoin

(Dilantin)

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Summary for Topamax

Prescription only

Topiramate (Topamax) belongs to the drug class called antiepileptics. It can be used alone or together with other medications to treat certain types of seizures in people 2 years and older. Topiramate (Topamax) can also be used to prevent migraines in people 12 years and older. It comes as immediate-release tablets and sprinkle capsules. The dosage is taken by mouth twice daily. Topiramate (Topamax) has many possible side effects, like weight loss and tingling of the arms and legs. It can also interact with many other medications.

Indications for Topamax

Pros and Cons for Topamax

Pros

  • Can take by itself or with other medications to control seizures
  • An option for preventing migraines
  • Also available as a sprinkle capsule that you can open and mix contents with soft food (for people who have trouble swallowing pills)
  • Approved for both adults and children (age depends on the health problem)

Cons

Common Side Effects for Topamax

  • "Pins and needles" feeling
  • Sleepiness
  • Dizziness
  • Fatigue
  • Low appetite
  • Weight loss
  • Nervousness
  • Depression
  • Trouble concentrating
  • Trouble remembering things
  • Trouble sleeping
  • Trouble moving or keeping balance
  • Fever
  • Mood changes
  • Change in taste

Warnings for Topamax

  • Vision problems
  • High body temperature and trouble sweating
  • Too much acid in the blood (metabolic acidosis)
  • Changes in mood and risk of suicidal thoughts or behavior
  • Problems with memory, speech, or coordination
  • Sleepiness, tiredness, and lower concentration
  • High ammonia levels in the blood
  • Serious skin reactions
  • Kidney stones
  • Risk of seizures if you stop the medication suddenly
  • Bone or growth problems in children
  • Interaction with other medications
  • Harm to an unborn baby

Summary for Dilantin

Prescription only

Phenytoin (Dilantin) is an antiepileptic medication used to treat and prevent seizures in adults and children. It comes in a capsule, chewable tablet, and liquid suspension that you take by mouth. The dose depends on your age, weight, and how well your seizures are controlled. Common side effects include trouble with coordination, unpredictable eye movements, and sleepiness. You’ll need regular blood tests to avoid toxicity, which is when the amount of medication in your body is too high and could be dangerous.

Indications for Dilantin

Pros and Cons for Dilantin

Pros

  • Available as a capsule, chewable tablet, and liquid suspension
  • Dose can be adjusted based on your response
  • Extended-release capsule can be taken once a day

Cons

  • Requires regular blood tests to check levels and determine the right dose
  • Common side effects include unpredictable eye movements and trouble with coordination
  • Can interact with a lot of other medications

Common Side Effects for Dilantin

  • Unpredictable eye movements
  • Trouble with coordination
  • Slurred speech
  • Sleepiness
  • Confusion

Warnings for Dilantin

  • Withdrawal seizures
  • Suicidal thoughts or behavior
  • Serious skin and allergic reactions
  • Heart problems
  • Liver problems
  • Lower blood cell count
  • Effects on Vitamin D and bone
  • Harm to unborn baby
  • High blood sugar levels
  • High phenytoin levels

Prices with our coupons for Topamax vs. Dilantin

Price Card Drug Icon
Topiramate30 tablets / 25mg
$5.50$5.50
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Phenytoin90 capsules / 100mg
$22.54$52.99
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