Compare Sulfasalazine vs. Colazal

Sulfasalazine (Azulfidine) and Balsalazide (Colazal) are both used to treat ulcerative colitis (UC), but they have some key differences. Sulfasalazine (Azulfidine) is an anti-inflammatory medication that also treats rheumatoid arthritis (RA) and polyarticular juvenile rheumatoid arthritis, while Balsalazide (Colazal) is specifically for mild-to-moderate active UC. Sulfasalazine (Azulfidine) is available in both immediate-release and delayed-release tablets, whereas Balsalazide (Colazal) comes in capsule form. You need to take Sulfasalazine (Azulfidine) with food to avoid stomach upset, but Balsalazide (Colazal) can be taken with or without food. Sulfasalazine (Azulfidine) can cause side effects like nausea, vomiting, and stomach upset, while Balsalazide (Colazal) commonly causes headaches, stomach pain, and diarrhea. Additionally, Sulfasalazine (Azulfidine) might affect your immune system and require regular blood tests, whereas Balsalazide (Colazal) does not weaken your immune system but still requires monitoring for kidney and liver health.