Key takeaways
Mesalamine DR (Lialda) and mesalamine DR (Apriso, Asacol HD, Delzicol, Pentasa) both contain mesalamine and are used for ulcerative colitis (UC). They help reduce inflammation in the gut, but they have some important differences. Mesalamine DR (Lialda) is specifically a delayed-release tablet taken once daily with food, while mesalamine DR (Apriso) comes in various forms, such as delayed-release tablets and extended-release capsules, with different dosing schedules. Lialda is approved for both adults and children, whereas most other mesalamine DR brands are for adults. Both medications are available as a lower-cost generic. Possible side effects include headache, stomach upset, and sun sensitivity. Both medications can interact with NSAIDs, increasing the risk of kidney problems, but Apriso should not be taken with antacids.
