Key takeaways
Mesalamine DR (Lialda) and balsalazide (Colazal) are both used to treat ulcerative colitis (UC), but they have some differences. Both medications belong to the same medication class called aminosalicylates and work by reducing inflammation in the gut. Mesalamine DR is a delayed-release tablet that is taken once a day with food, whereas, balsalazide is a capsule taken three times a day. Additionally, balsalazide can be taken with or without food, and its capsules can be opened and sprinkled on applesauce. Balsalazide may work better than mesalamine for UC flare-ups. Both medications can cause kidney and liver problems and a specific reaction called mesalamine-induced intolerance. Balsalazide can cause respiratory tract infections and joint pain, which is not common with mesalamine DR.
